在线发表于2013年11月7日的《胸外科年鉴》(Ann Thorac Surg)杂志上。研究发现，支架象鼻技术可以替代治疗逆行性A型主动脉夹层，手术风险可以接受，结果...逆行性A型主动脉夹层是B型主动脉夹层胸主动脉腔内修复术后罕见但致命的并发症。全弓置换与改良后后的支架象鼻技术（SET

半衰期延长的重组因子 VIII Fc 融合蛋白，该药物将是欧盟首个能对出血发作提供延长保护的血友病 A 治疗药物，其每 3-5 天进行一次预防性注射。「对...的里程碑Elocta 旨在用于所有年龄血友病 A 患者的按需及预防性治疗。此次欧盟委员会的批准基于 Elocta 的 3 期 A-LONG 及 Kids

长江商报记者 傅坚 摄扫描骨折数据后，用3D打印机打出1:1的仿真模拟，武汉协和医院专家提前操刀演练，节约一半时间精准定位、修复严重骨折。目前，这套“私人...，再将这个源文件输入计算机，编辑转化为三维模型，导入一台3D打印机，按1:1的比例，用特殊材质打印出一个仿真局部骨折模型。刘国辉教授说，这样一来，一改过去手术

）上，德国 T.Wehrum 等的研究团队向大家介绍了利用 3D 多对比 MRI 与 4D 动态 MRI 技术对隐源性卒中和对照组患者的主动脉斑块形态和栓塞风险评估。40 例隐源性卒中患者和 60 例来自眼科的对照患者接受了 3D 多对比 MRI 扫描，研究者对主动脉斑块的形态、部位及易损程度（表面情况、斑块成分、钙化

1 型。定性诊断思路如下：图 3 定性诊断思路基于临床和电生理结果考虑 CMT1 诊断，用多重连接探针扩增技术（MPLA）行 PMP22 基因检测发现片断重复。患者父母无明显肢体麻木无力主诉，基因检测发现父亲亦存在 PMP22 基因片断重复。最终诊断：Charcot-Marie-Tooth 1A 型

2pm～5pm在中山楼7楼707室或26日8am在岭南楼26楼海珠厅。办班地点：中山大学孙逸仙纪念医院（附属第二医院）岭南楼26楼海珠厅。招生...医院岭南楼26楼海珠厅上课时间：上午8:30am～12:00am，下午2:30pm～5:30pm，晚上7:00pm～10:00pm。备注：课程表及手术演示

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

切除术20余例，胆总管探查取石术2例，脾脏切除术4例，胃癌根治术8例，肝脏切除术15例，胰十二指肠切除术1例，取得了较为满意的效果。作为腹腔镜技术的新探索，现将3D辅助...手术和腹腔镜小切口辅助手术。2005年浙江大学医学院邵逸夫医院在蔡秀军教授的带领下就顺利完成了1例完全腹腔镜胰十二指肠切除术。运用3D腹腔镜技术行胰

ICSB 2011: Intl Workshop on Cancer Systems Biology (Jul 2-3, 2011)Link: http://ccst.jlu.edu.cn/icsb2011/July 2-3, 2011 Jilin University, Changchun

图1X线胸片示上纵隔一巨大肿物；图2 纵隔窗示上纵隔一巨大肿瘤，边缘光滑，呈分叶状，凸向左侧胸腔，密度欠均匀，其内未见钙化，纵隔内血管受压，向右、向下移位。主支气管受压狭窄；图3 免疫组化，瘤细胞对CK19染色呈阳性表达SP×100；图4 免疫组化，瘤细胞对CAM5．2染色呈阳性表达SP x 100患者女，29岁。因咳嗽1个月，发热7天就诊。查体未发现阳性体征，血肿瘤标志物结果正常。胸部X线片示上纵隔一巨大肿物，大小8 cm×7 cm×8cm，壁光滑(图1)。胸部CT示上纵隔巨大肿物，呈分叶状，8cm×9cm×10cm大小，凸向左侧胸腔，密度欠均匀，其内未见钙化，纵膈内血管受压，向右、向下移位，见图2。主支气管受压狭窄。纵隔内未见明显肿大的淋巴结。双侧胸腔内少量积液，心包无积液。查看更多

。生长激素释放肽是有消化道上皮细胞表达，并受肝细胞核因子1A(HNF1A)调节[一种突变可导致的青少年发病成年型糖尿病（MODY）的转录因子]。如动物模型所示，与野生型小鼠相比，HNF1A敲除纯合子小鼠（Hnf-/-）生长激素释放肽表达增加大约5倍。此外，紧随其后是血清生长激素释放肽浓度增加五倍，随后胰岛素分泌减少。人类

CVD发生率。根据弗雷明汉风险评分（FRS）和雷诺兹风险评分（RRS）变量调整后的模型，Lp(a)水平每升高1-SD（32 mg/dl），CVD事件的风险比为...近期研究显示，脂蛋白（a）（Lp(a)）是心血管疾病（CVD）的致病风险因子，但Lp(a)能否影响临床风险的评估仍不清楚。近日《美国心脏病学杂志》发表

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3D 打印技术正在快速增长，其市场之一是医疗保健行业，它一直在以惊人的速度开发新的医疗应用。曾经它只是 3D 打印大潮中一个小小的浪头，而现在已经在这个行业...研究报告将医疗 3D 打印产业分成几个类别和子类别，其中包括通常使用的技术如熔融沉积成型（FDM）、激光束熔化（LBM）、电子束熔化成型（EBM）和光固化（SLA

百济神州（BeiGene）公司于 2016 年 1 月 8 日宣布，美国食品药品管理局（FDA）已经通过了其候选药物 BGB-A317 进行新药临床试验的申请。该药物是一种针对免疫抑制性受体 PD-1 的全人源单克隆抗体。这将允许百济神州在美国进行临床试验并纳入其目前关于使用 BGB-A317 治疗复发性或难治性

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