一项最新的研究发现，有一类不正常基因，总比其他健康人群，更有普遍的存在与Ⅱ型糖尿病的患者身上。\r\n\r\nⅡ型糖尿病患者已知存在高癌症风险，特别是像淋巴瘤和白血病这样的血癌。由英国伦敦帝国理工大学和法国法国科学研究中心带领的科学家们，最近表示：一种称为“克隆马赛克事件（CMEs）”的基因，可能可以解释这一人群疾病的部分问题。

骨和内分泌的经典之作！ \r\n\r\nAdvances made during the last 35 years have improved our understanding of the mechanisms of steroid hormone action on bone and how physiologic, pathologic, or iatrogenic changes in hormone levels can lead to increased fracture risk. Estrogens, androgens, and glucocorticoids alter the cellular composition of bone by regulating the supply and lifespan of osteoclasts and osteoblasts. Additionally, they influence the survival of osteocytes, long-lived cells that are entombed within the mineralized matrix and mediate the homeostatic adaptation of bone to mechanical forces. Altered redox balance is a proximal underlying mechanism of some of these effects, and sex steroid deficiency or glucocorticoid excess contributes to the aging of the skeleton.

Brachytherapy (BT) plays a crucial role in the management of invasive cervix cancer from stage I to IV.\r\nIntracavitary techniques are based on afterloading devices, with different types of applicators. CT and/or MRI compatible applicators allow a\r\nsectional image based approach with a better assessment of gross tumour volume (GTV) and definition and delineation of target volume (CTV) compared to traditional approaches. Accurate and reproducible delineation of GTV, CTV and PTV, as well as of critical organs has a direct impact on BT treatment planning, especially if it is possible to adapt the pear-shape isodose by optimisation using DVH analysis. When introducing a 3D image based approach for GTV and CTV assessment, there is a need for a common language to describe the concepts and to define the terms which are to be used.

Epidemiology of Infectious Diseases-1Infectious Disease... Disease Process-40Reproductive Number, R0-41Reproductive

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复旦大学附属肿瘤医院的章真教授进行了每周伊立替康联合卡培他滨结合新辅助放疗治疗 UGT1A1 基因野生纯合型（TA6/6）的局部晚期直肠癌的研究，证实了该方案...纳入 52 例患者，平均年龄 54 岁。纳入标准为：临床分期为 T3～4, N0～2 ，可接受术前化疗，且 UGT1A1 基因野生纯合型的局部晚期结直肠癌

本病例由丁香园网友neversayno提供。患者女，15岁，学生，因双下肢浮肿伴尿检异常1月2006-5-23入院。患者入院1月前无明显诱因下出现双下肢.../分，R20次/分，BP112/56mmhg。神志清，颜面无浮肿，巩膜无黄染，两扁桃体无肿大，颈静脉无怒张，两肺呼吸音粗糙，未闻及罗音，心率101次/分，心律齐

基础上，提出关于 α１ 激动剂围术期规范化应用专家共识。α１ 激动剂的药理学特点人体不同部位血管表面 α 1- A R 分布不同，缩血管药物反应也不同。如冠状动脉 α 1- A R 密度较低，肺动脉、肾动脉和肝动脉 α 1- A R 密度较高。 α 1- A R 亚型分为α 1 A 、 α 1 B

Int J Cardiol 2011 Oct;152 (1): 28-34. [IF:6.802]Diastolic ventricular..., RV SRe correlated with left ventricular (LV) SRe (r=0.49, p=0.008), and RV SRa

脾胰肾等未见异常。肾上腺彩超未见异常，甲状腺彩超未见异常。心电图正常。血常规正常。复查尿糖1+。治疗：优泌乐50R皮下注射，血糖空腹及餐前比较理想...xinzangbingke：男性，27岁，以“多饮多食体重下降1个月，下肢水肿1周”于2011年3月12日入院。平素健康。1个月

目的 探讨第 1 跖骨近端新月形截骨克氏针内固定联合软组织松解治疗中重度拇外翻的疗效。方法 2005 年 6 月至 2013 年 6 月采用第 1 跖骨近端新月形截骨克氏针内固定联合软组织松解治疗中重度拇外翻病例 41 例 (44 足), 获随访 27 例 (30 足)。术后通过影像学检查

该试剂盒采用夹心法ELISA原理，定量检测小鼠和人中的重要指标，并经过细胞培养上清液严格优化，保证了ELISA检测的灵敏度，重复性，特异性。ValukineTM与R&D Systems®其他ELISA试剂盒的区别 

AydinO’Dwyer教授、David R. Hinton教授、Chiea Chuen Khor教授、Stephen Tsang教授

可通过酪氨酸磷酸化与SHP-1结合，当其与Fcγ链受体（FcγR）Ⅰ相互链接时，可抑制FcγR Ⅰ和脾酪氨酸激酶（SyK）的酪氨酸磷酸化，并诱导细胞内钙的释放。另有研究发现LIR-1和LIR-2可抑制FcγR1介导的单核细胞活化，提示SHP-1是这一调控轴的负性调控因子

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