剖宫产术，患者出生体重为4.5kg。患者饮食以精制碳水化合物和单糖为主。有2型糖尿病家族史。患者体重、体重指数和身高高于同年龄、同性别人群的第95百分位数，分别为36kg、24.5kg/m2和123cm。双侧大腿和右侧腋窝可见陈旧性溃疡，符合脓疱病的临床表现。腋窝和颈部可见黑棘皮症，余查体未见明显异常

Stefan M. Pulst等进行了一项meta分析，旨在进一步明确ATXN2 CAG重复序列大小与多种族人群中ALS风险增加的相关性。该研究结果发现，中等...脊髓小脑共济失调2型（SCA2）是一种由于共济失调2型基因 (ATXN2)N末端谷氨酸重复扩增所致的一种罕见的常染色体显性神经退行性疾病。然而，近期越来越多的

：fetalechosrrsh@126.com电 话：0571－8600633113738132108（李世岩）13819169149（周林...;温馨提示：1、报名请优先采用E-mail方式2、杭州宾馆较为紧张，请尽快报名及确认是否住宿

（如急性冠脉综合症、脑血管意外和心衰）的相关资料，并进行回归分析。结果显示，与体重正常（BMI 18.5-24.9 kg/m2）的患者相比，超重或肥胖（BMI≥25 kg/m2）者心脏事件（如急性冠脉综合症和心衰）的发生率更高。然而，在生存方面，肥胖（BMI > 30  

BISMiS 2011北京伯杰氏国际微生物系统学学会成立大会摘要征稿截止日期:2011年2月15日优惠注册日期:2011年...征求会议摘要（报告或展板），参会者请于2011年2月15日前登录会议网站（www.bismis.org）通过摘要提交系统进行提交。会议日程本次会议

糖蛋白 1（EGP-1）、胃肠道抗原 733-1（GA733-1）、膜表面标志物 1（M1S1）[1]。由于 Trop-2 在大多数人类癌症中高表达，但在正常组织...):5147-5150.[2]Trerotola M,Cantanelli P, Guerra E, et al. Upregulation of Trop-2

://www.burnscn.com右上角会议链接，或直接登录http://m1605.meeting163.com）。注册付款后发送短息至15308980032确认...://www.tienyow.com/住宿：会议酒店是五星级海景酒店，注册会议代表享有优惠权，标准双人间400/天，参会代表合住者200/人（含

Tel：15300029271电子邮箱：puemed@163.com官方网站：www.puem.org

第三届医疗器械制造定制服务技术创新论坛主办：国药励展2015年05月16日 09:00-12:006号馆M6-01会议室CMEF OR-手术室一体化新进展论坛主办：国药励展2015年05月17日 14:00-17:007号馆M7-04会议室2015年康复养老市场政策研讨会主办：国药励展2015年05月15日

摄入。超重（BMI 在 25~29.9 kg/m2）或肥胖（BMI ≥ 30 kg/m2）的患者应至少降低体重 5%~10%。在 Look AHEAD 和糖尿病...或强化减肥治疗。所有超重或肥胖患者应进行生活方式治疗，有并发症的患者治疗更加严格。如减肥药物联合生活方式治疗可用于 BMI ≥ 27 kg/m2且伴有并发症的患者

; 金医生 E-mail:shcsxxb@163.com 

，M D Anderson Cancer Center主办，第七届会议将来到中国上海，由上海交通大学医学院和美国德州大学M D Anderson 癌症研究中心

包：A 国内企业（3M×3M）12800元/个标准展位。境外企业（3M×3M）$3000美元/个标准展位。B 供希望...：+86-10- 69552554傳真：+86-10- 69551747 E mail：hanlm5210@163.com

为1.75-3.10]）。受试者平均体质指数在1984年至1999年间上升了1.42kg/m2（95％ CI:1.10-1.74），可以解释26％（95％ CI...伦敦大学人口健康中心的Sarah L.Hardoon等人进行的一项研究表明，英国成年男性2型糖尿病发病率的上升的原因，一定程度上可归因于体质指数（BMI

胼胝体的冠状位T2成像的放大图以及LCN2免疫组化结果。方形区域为低倍显微镜下所见，(比例尺= 200和50μm)。图B为LCN2，神经胶质纤维酸性蛋白 (GFAP)和Iba-1免疫反应性，以及LCN2 与GFAP 或Iba-1双重标记后融合成像(比例尺= 50μm)。在野生型SAH小鼠中

ccvideo中山大学附属肿瘤医院吴沛宏教授及其团队的研究细分 M1 鼻咽癌的 SMART 策略，入选本届大会的壁报单元。吴教授在接受丁香园专访时说，SMART 策略可用于鉴定转移性鼻咽癌（mNPC）有治愈机会的病人，需要更多的试验评估可行性，以及在靶标病人获得完全缓解的重要性。

中山大学附属肿瘤医院吴沛宏教授及其团队的研究细分 M1 鼻咽癌的 SMART 策略，入选本届大会的壁报单元。吴教授在接受丁香园专访时说，SMART 策略可用于鉴定转移性鼻咽癌（mNPC）有治愈机会的病人，需要更多的试验评估可行性，以及在靶标病人获得完全缓解的重要性。

InstituteGabrielle A. Carlson, M.D., ChairJanuary 25-26, 2013

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer