间，3,047 名患者接受了 GLP-1RA 治疗（其中 97% 为联合降糖方案），中位使用时间为 0.8 年（最长 7.3 年）。随访期间，共 10,763 名...;373:2247–2257.[2] Marso SP, Daniels GH, Brown-Frandsen K, et al.; LEADER Steering

141/91mmHg，心率 102 次/分， 血氧 97%（未吸氧）。全身水肿，颈静脉扩张和右侧肺部听诊呼吸音减低。实验室检查...）。Javier A. Neyra, Omkar U. Vaidya, Allen Hendricks, Kamalannathan K. Sambandam

结果为 IGT，则需每 3 个月随访 1 次。(3) 生活方式的干预：一般建议非母乳喂养的妇女产后热量摄入为 104.6 k J/（kg·d），母乳喂养的妇女为 113.0～125.5 k J/（kg·d）。 膳食纤维可提高胰岛素敏感性。富含纤维的食物包括豆类、谷物、水果、蔬菜、全麦面包、低脂奶等。结合有规律的锻炼：每日最少

降低时间、血栓形成和其它引起血小板减少的原因，每项指标评分 0-2 分，累积分值越高，HIT 可能性越大。总分小于 4 分，阴性率达 97%-99%，总分... K 拮抗剂只能在 HIT 缓解（例如连续两次血小板计数超过 150x109/L）后使用，因为此类药物增加下肢坏疽风险，启动维生素 K

Stroke. 2009 Nov;40(11):3461-5.9. Tanino T, Kanasaki Y, Tahara T, Michimoto K, Kodani K, Kakite S, Kaminou T, Watanabe T, Ogawa T. Radiation-induced microbleeds

第九版《病理生理学》上给的解释：镁缺失，可使肾小管上皮细胞Na+-K+-ATP 酶失活，钾重吸收障碍，导致钾丢失过多。然而，这样的解释经不起深究，因为 Na+-K+-ATP 酶分布实在是太广泛了，如果说低镁血症引起 Na+-K+-ATP 酶活性减低，那么由此导致的后果绝对不仅仅只有低钾血症。原理在远端肾单位

质和量异常，结合患者应用头孢哌酮舒巴坦病史，考虑静脉输注头孢哌酮而引起成人获得性维生素K 依赖性凝血因子缺乏症，予以维生素 K1 20mg 静滴 2 天后复查凝血功能，PT 恢复正常。那么问题来了维生素 K 在机体凝血过程中究竟扮演着什么样的角色，头孢哌酮舒巴坦是如何影响维生素 K 参与凝血过程的呢？维生素

。Copanlisib 是一种静脉注射用磷脂酰肌醇-3 激酶（PI3K）抑制剂，PI3K 通路参与细胞生长、生存及代谢，Copanlisib 对 PI3K-α和 PI3K...及中位无进展生存期正接近一年。Copanlisib 间歇性使用，每三周连续用药，每周输注一次，每次 1 小时，然后停药一周。拜耳正在追赶吉利德科学的 P13K

V-Alexa Fluor647/PI(4abio-FXP023)3. Annexin V-FITC/PI 细胞凋亡检测试剂盒 (K 品牌)4. Annexin V-APC/PI 细胞凋亡检测试剂盒 (K 品牌)5. Annexin V-FITC/PI 细胞凋亡检测试剂盒 (e 品牌

压缩；胫骨脊受累以及需要固定的胫骨结节分离。统计分析结果显示，3D-CT重建可在如下骨折特征方面显著改善观察者自身的可重复性：冠状面骨折（平均k2D = 0.700, 四分位数间距(IQR): 0.551–0.820 vs. 平均k3D = 0.774, IQR: 0.692–

方面的论文已经收回。该研究者究竟是何许人也？其实这些被撤稿的7篇论文是由一名杰出的印度免疫学家Sunil K. Manna所写，由于图像处理问题在过去的一个月之内相继撤稿。这些论文报告了作者在癌症细胞分子生物学方面的一些发现。Sunil K

;0.0005）。对于观察者间可靠性，大量总体值：肌腱炎灰度（GS）值是80-89%，PPD信号是97-100%，IPD信号是97-100%，肌腱损害灰度（GS）值97-100%。结果独立于扫描技术。研究者认为：肌腱炎和肌腱损害的观察者内部可信度从中等灰度（GS）值到高等多普勒（PD）不等。肌腱炎和肌腱损害的

Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

首届中国PBPK模拟软件GastroPlus Workshop第二轮通知

北京·2012年5月16-18日

上海·2012年5月21-23日尊敬的老师，您好！生理药代动力学模型（PBPK）在药物研发与监管中得到广泛应用意味着新时代的来临！它改变了动物试验和人体实验传统研究模式流程，指导制药企业项目决策及效率提高；FDA和EMA的使用及推荐，促使国外制药企业及学术单位相关研究者都在学习及掌握PBPK的应用。为促进我国在该领域的发展，力争与全球同步，凡默谷特邀美国Simulations Plus顶尖专家来华授课，让您了解及掌握PBPK知识、获悉国外最新应用、亲授多年使用经验，授课过程将以理论与实践相结合的形式进行。GastroPlus是由美国Simulations Plus公司研发的基于机制性生理模型的药代动力学、药效动力学(PBPK/PD)模拟软件，目前在FDA和几乎所有的全球顶尖制药公司中得到广泛应用，被誉为同类软件中的“黄金标准”。为确保培训效果，限额50人/班，第一轮通知发出后，已得到广大中国用户的积极响应和踊跃报名。报名从速！为何本次GastroPlus Workshop值得您参加？1）药物研发及监管中争相应用PBPK模型的时代已经来临！2）PBPK辅助药物研究可方便指导项目决策、节约成本、缩短时间；3）FDA已广泛采用PBPK模拟来制定法规和对新药及仿制药进行审批；4）FDA及各大制药企业对全球最权威的PBPK模拟软件GastroPlus倍加青睐；5）零距离接触Simulations Plus首席科学家，并参与学习的最新应用案例；6）您可免费获得一个月的GastroPlus软件试用。本次GastroPlus Workshop将让您受益良多：1）制药企业或CRO：有利于您理解您的客户或其他Sites实验方案设计思路、下一阶段决策及实验开展、合理设计实验方案；2）学术研究：启示您开辟新的药代、药剂等研究方向，剖析药物作用机制等；3）临床药理研究：合理设计临床试验方案，不同人群PK/PD研究等；4）法规部门：协助制定新药及仿制药政策和标准。报名方法：请您填写报名回执，并通过Email的方式反馈给我们。Email: training@pharmogo.com报名截止：2012年4月20日(北京培训班)/2012年4月30日(上海培训班)联系人：周伟,电话：021-61638583-8001报名确认：1）报名确认以凡默谷收到款项或报名者提供汇款凭证为准，凡默谷可先提供发票以供报销；2）会务组在接到报名后，将email或电话通知学员培训班相关事项。温馨提醒：学员必须自带已安装好Gastroplus程序的电脑参加培训，现场不提供电脑。

GastroPlus Workshop Course Instructors List

Michael B. Bolger Chief Scientist Simulations Plus Inc.	Dr. Bolger is Chief Scientist at Simulations Plus, he oversees a team of scientist / programmers at Simulations Plus, Inc. (Lancaster, CA) in the development of software programs (ADMET Predictor/Modeler, MedChem Studio/Designer, GastroPlus, DDDPlus, and MembranePlus) for estimation of biopharmaceutical properties, simulations of absorption and bioavailability, automated generation QSP/AR model building, in vitro dissolution, and cell culture permeability simulation. As a faculty member at USC School of Pharmacy, his research was supported by several NIH basic science research grants and he published over 50 peer-reviewed publications. From 1989-1991 he served as a FDA National Science Advisor. He has served as a reviewer for numerous scientific publications. He is currently Adjunct Associate Professor of Pharmaceutical Sciences at USC.
Haiying Zhou, Ph.D. Senior Scientist II Simulations Plus Inc.	Dr. Zhou is Senior Scientist II at Simulations Plus, she focused on the development of modeling and simulation software for quantitative understanding of the pharmacokinetics and pharmacodynamics of drug candidates (GastroPlus), in vitro dissolution of active pharmaceutical ingredients and formulation excipients under various experimental conditions (DDDPlus). She received her M.S. degree in automation from East China University of Science and Technology (ECUST) in 2002 and her Ph.D in Biomedical Engineering from Case Western Reserve University (CWRU) in 2009. Her research interests in CWRU include multi-scale mathematical modeling of gas transport and cellular metabolism with emphasis on the metabolic regulation during different conditions, e.g. hypoxia and exercise.
John DiBella Vice President of Marketing Simulations Plus Inc.	John DiBella is the Director – Marketing & Sales at Simulations Plus, He joined Simulations Plus in 2003 and has spent time working on the development of GastroPlus? and DDDPlus? software and consulting projects. Now, he leads the marketing & sales activities for the company while continuing to travel the world hosting training seminars.John obtained B.S. and M.S. degrees (with honors) in Biomedical Engineering from Case Western Reserve University in 2003. His graduate research was focused on computational modeling of physiological systems.

培训班详情：请下载附件参加北京培训班请点击下载：GastroPlus北京培训班第二轮通知/BeiJing GastroPlus-Intro-Workshop 2nd Notice参加北京培训班请点击下载：GastroPlus上海培训班第二轮通知/ShangHai GastroPlus-Intro-Workshop 2nd Notice