Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

的更具体的影响，也不知道什么样的方案才能恢复患者的健康。为了寻找答案，美国政府找到了在生理学界小有名气，并曾经为美军设计了行军盒饭K-口粮（K-ration）的明尼苏达大学的生理学家 Ancel Keys。1941年Keys为美军设计的K-口粮早饭 图片来源：wikipedia在美国军方的资助下，1944 年 11 月

%、69%及62%。脑病、腹水、凝血酶原时间延长及胆红素增高是独立的不良预后因素。另一项针对163例BCS患者分析发现，1年、2年生存率分别为87%及82%。一项纳入173例PVT患者的回顾性分析发现，中位随访2.5年，1年、5年总生产率分别为69%及54%；但排除肿瘤及肝硬化患者后，其可分别达92%及76%。多因素分析发现

致电：第十七届中国国际医药（工业）展览会暨技术交流会地 址：上海市菊盛路50弄69号502室电 话+86

、23路、591路、151路、69路等均可到达。 

，定医未来」为主题，以「4K」高清晰画质为先锋，结合智能易用的医疗管理方案，开拓医疗业务的新局面。索尼中国医疗业务如何取得如此骄人成就？未来在医疗领域还将...的重点，是 4K 影像解决方案，包括由 4K 术野摄像机、4K IP 传输设备、4K 监视器、4K 录像机、等设备组成的从信号采集、信号传输到画面监看录制的完整