Background. Increased pneumococcal loads are associated with severe outcomes. We determined the prevalence of pneumococcal DNA in blood specimens from patients hospitalized with acute lower respiratory tract infection and identified factors associated with invasive pneumococcal pneumonia, bacterial loads, and death.Methods. A total of 8523 patients were enrolled as part of prospective hospital-based surveillance. Blood was collected for quantitative pneumococcal (lytA) detection, and nasopharyngeal specimens were collected for detection of influenza virus and other respiratory viruses by real-time polymerase chain reaction.Results. Of 6396 cases (75%) with lytA results, 422 (7%) were positive for pneumococcal DNA. The prevalences of human immunodeficiency virus (HIV) and influenza virus were 51% (2965/5855) and 8% (485/6358), respectively. On multivariable analysis, HIV infection (adjusted odds ratio [aOR], 2.4; 95% confidence interval [CI], 1.6-3.6), influenza virus coinfection (aOR, 1.4; 95% CI, 1.2-2.1), oxygen therapy during admission (aOR, 1.6; 95% CI, 1.1-2.3) and in-hospital death (aOR, 2.1; 95% CI, 1.1-4.0) were significantly associated with increased pneumococcal load. Among lytA-positive patients, after adjustment for length of hospitalization, duration of symptoms, and oxygen therapy during admission, pneumococcal loads ≥10,000 DNA copies/mL (aOR, 3.6; 95% CI, 1.8-7.2) were associated with increased risk of death.Conclusions. HIV and influenza virus infections were associated with elevated pneumococcal loads, which, in turn, were associated with increased risk of death.

。阿法依泊汀是一种促红细胞生成素，又称重组人红细胞生成素。所有促红细胞生成素类药品说明书中，推荐通过治疗达到的最大血红蛋白浓度不超过12g/dL。CHOIR研究目的在于对非透析肾病患者接受阿法依泊汀治疗的风险和效益进行评估。研究发现，若使用阿法依泊汀将血红蛋白浓度升高到13.5g/dL，较将血红蛋白升到

7 月 18 日，杭州玉皇山庄附近，一辆电动自行车在行驶途中突然起火。父亲被紧急送往浙江大学医学院附属第二医院, 全身多处火焰烧伤 95% 三度 75%。后来...哪些配合？大面积烧伤患者的治疗，困难重重像 95% 三度 75% 烧伤病人，无论放在国内外任何一个大的烧伤中心进行治疗，难度都是非常大的。一、早期出现了多脏器

小宝宝由于消化系统、神经系统发育不完善，很容易出现便秘的现象，但在 1 岁及以上的健康儿童中，95% 以上的便秘为功能性便秘。（功能性便秘是指持续性排便困难...情况，建议就医儿童便秘的发生率为 3%-30%，其中 95% 以上是功能性便秘。对于常规治疗无效的宝贝，或伴有腹痛、呕吐、腹胀、体重不增等情况，请及时寻求医生的

1 月 24 日中午，河南省首批援冀医疗队 95 名队员圆满完成各项救援任务，胜利凯旋。一方有难，八方支援，1 月 13 日援冀医疗队出征，郑州人民医院 6...，河南省卫健委抽调郑州大学第一附属医院等 7 家驻郑省直医院和郑州市紧急医疗救援中心、郑州市中心医院等 8 家郑州市直单位的 95 人，组成河南省援冀医疗队，同时派出

Kidney International 杂志上发表了有关非典型溶血尿毒综合征（aHUS）和 C3 肾小球病（C3 G）这两种典型的补体介导的肾脏疾病的专家共识...至 ESRD 阶段了。C3 G 也是一种极其少见的疾病（发病率约为 1/百万人/年），定义为一组不可治愈的肾脏疾病，由于不受控制的补体激活导致 C3 沉积在肾小球内

JE, Diercks DB, Lopatin M, Fonarow G, Emerman CL. Morphine and outcomes in acute...;ehab368. doi:10.1093/eurheartj/ehab368.[3] Orso D, Boaro G, Cassan E, Guglielmo N.

：[1] Peacock WF, Hollander JE, Diercks DB, Lopatin M, Fonarow G, Emerman CL....].Eur Heart J. 2021;ehab368. doi:10.1093/eurheartj/ehab368.[3] Orso D, Boaro G

。研究纳入SLE患者258例，以及年龄、性别和居住地匹配的对照263名。结果为，户外工作与12个月内诊断为SLE相关［比值比（OR）=2.0，95%可信区间（CI）为1.1~3.8］，其中，正午阳光照射后出现疱状晒斑或皮疹者相关性最强（OR=7.9，95%CI为0.97~64.7）；从事颜料、染料、胶卷

据在线发表于《疼痛学杂志》上的一项Ⅲ期临床试验(n=660)结果，释药量为20 μg/h的阿片类药物丁丙诺啡透皮贴剂对中至重度慢性腰背疼痛(LBP)患者疼痛评分的改善效果明显优于释药量为5μg/h的丁丙诺啡透皮贴剂或阳性对照药物羟考酮速释胶囊(doi