【编者按】近期，哥伦比亚大学医学中心的Généreux博士等在JACC上发表了一篇关于经导管主动脉瓣置换术后主要晚期出血并发症及其与死亡率之间关系的文章，来自...预后的影响至关重要。为此，来自美国哥伦比亚大学医学中心的Généreux博士等进行了一项研究，研究发现经导管主动脉瓣置换术后主要晚期出血并发症常见，且增加死亡率

Background. Children are highly vulnerable to infection with novel influenza viruses. It is essential to develop candidate pandemic influenza vaccines which are safe and effective in the pediatric population.Methods. Infants and children aged 6-35 months and 3-8 years were randomized to receive two immunizations with a 7.5 µg or 3.75 µg hemagglutinin (HA) dose of a non-adjuvanted whole-virus A/Vietnam strain H5N1 vaccine; adolescents aged 9-17 years received a 7.5 µg dose only. A subset of participants received a booster immunization with an A/Indonesia strain H5N1 vaccine approximately one year later. HA and neuraminidase antibody responses were assessed.Results. Vaccination was safe and well-tolerated; adverse reactions were transient and predominantly mild. Two immunizations with the 7.5 µg dose of A/Vietnam vaccine induced virus neutralization (MN) titers ≥1:20 against the A/Vietnam strain in 68.8% to 85.4% of participants in the different age groups. After the booster, 93.1% to 100% of participants achieved MN titers ≥1:20 against the A/Vietnam and A/Indonesia strains. NA-inhibiting antibodies were induced in ≥90% of participants after two immunizations with the 7.5 µg A/Vietnam vaccine and in 100% of participants after the booster.Conclusions. A whole-virus H5N1 vaccine is suitable for pre-pandemic or pandemic immunization in a pediatric population.

eBC患者辅助赫赛汀治疗未使用辅助化疗-48《HER2阳性乳腺癌临床诊疗专家共识》-3H0648g...从初始治疗开始观察总生存-32辅助赫赛汀治疗小肿瘤的研究-46各研究证实曲妥珠单抗治疗的心脏事件

为促进中外肿瘤专家学术交流，和睦家肺癌诊疗中心与和睦家启望肿瘤中心将在 11 月 21 日下午 7：00 面向医疗同道共同举办海外名医讲堂，特邀哈佛大学医院附属麻省总医院 Dr. Christopher G. Azzoli 医生连线分享《非小细胞性肺癌（NSCLC）治疗 2017 年新进展》，欢迎多学科专家共同参与

OSAHS引起糖尿病的机制-14osahs与糖尿病-1IL6-22OSAHS与糖尿病的共存机制-9TNFa-23持续气道正压通气治疗-43持续气道正压通气治疗-44打鼾 白天嗜睡-28癫痫-33反复发生脑血管疾病-32对象-45方法-46方法-52肥胖-11肥胖，IR，糖尿病控制困难

正常脑生理-9“隆德”治疗方案-39ICP持续的高于25~30mmHg-45CO2的脑血流量调节-17ICP持续的高于25~30mmHg-46

癌症病人的饮食-1便秘的病人-45白细胞数少的病人-47便秘的病人-46不同治疗副反应和相关症状的饮食管理-41蛋白质-11

“生存链”是提高CPR成功率的唯一有效途径-54CPR第二阶段——第二个ABCD-46

12条-27苯溴马隆-44别嘌呤醇的副作用-47发病机制-11传统NSAID胃肠损害的预防-38别嘌呤醇的用法-46非甾体抗炎药-37分类-15高尿酸血症患病率变化趋势-8急性关节炎期的治疗-35急性痛风性关节炎的临床特点-21降尿酸药物的使用原则-41鉴别诊断-29降尿酸治疗-40降

定义-3放射学-46放射学-47分类新标准-24

和处理报警的一些注意事项-46高压报警-29高压报警-28高呼吸频率报警-35

NEMC-PCR等研究证明-34PCI常见临床症状-30CRP-38PCI几个重要认识（小结）-46The Dix-Hallpike Test-37背景-4

处理小结-46高血压急症的发病机制-11高血压急症的临床表现-6高血压急症的诊断和治疗-1高血压急症的治疗-12高血压急症和高血压次急症的主要异同

患者，男，46岁，因进行性视力下降行MRI检查，示脑膜多灶性结节状增厚，累及视神经附近双侧脑膜和内耳门处脑膜（图1），遂诊断为弥散性多发性脑膜瘤行放射治疗后症状稳定。4年后出现左侧听力丧失并右侧听力下降，使用高剂量地塞米松冲击治疗后症状即有所恢复。血浆免疫球蛋白IgG4增加。脑脊液检查显示蛋白升高，寡克隆

CHOP ± 美罗华治疗初治FL的PFS比较-47CHOP美罗华用于初治的滤泡型淋巴瘤-46Allo HSCT移植适应证-50Fever and systematic symptoms-25

ARDS 死亡率-31ARDS 死亡率-32ARDSnet 临床研究-40ARDS机械通气与综合治疗-1ARDS 药物治疗-34ARDS与PE-45ARDS重大事件-2ECMO-50ARDS与PE-46PEEP-17PEEP高或低？-18PEEP高或低？-19ECMO-51PEEP设定

2002 美国镇痛、镇静指南推荐-35ICU的镇静-45ICU“达标镇静”-18ICU“达标镇静”急需观念上改变-6ICU的镇静-46

颈椎病是否与眩晕有关-49良性发作性位置性眩晕-32临床表现-46临床表现