Fmoc-Ile-OH U-13C6，15N Fmoc-Ile-OH 1-13CP Fmoc-Pro-OH U-13C5，15N Fmoc-Pro-OH U-13C5L Fmoc-Leu-OH 15N  

【今日问答】抢救糖尿病酮症酸中毒时，胰岛素最佳用量为?A.4〜6 U/hB.6〜10 U/hC.10〜20 U/hD.20〜30 U/hE.30〜35 U/h解析：一般采用小剂量（短效）胰岛素治疗方案，即 0.1 U/kg·h(成人体重 4〜6 U/h)，使血清胰岛素浓度恒定达到 100-200 μU/ml（选 A

），HBsAg 5850.00IU/ml，HBeAg 6.2S/CO，AntiHBc 107.12S/CO。ALT 53.7 U/L，AST 31.6U/L，TBIL...在我院住院，化验肝功 ALT 13.1U/L，AST 17.1U/L，TBIL 15.0umol/L，ALB 43.3 g/L，GGT 8.9U/L，ALP

：0-8umol/L）、间接胆红素：25.2umol/L（参考范围：0.5-20.0umol/L）、胆碱酯酶：2011U/L（参考范围：5000-13500U/L）、总胆汁酸...、胆碱酯酶：2016U/L、总胆汁酸：251.9umol/L、前白蛋白：85 mg/L、尿素：14.4 mmol/l、血肌酐：123umol/L。考虑该患者服用

（参考范围在 27-102 μg/dL）。随后的肝功能检查结果中：丙氨酸氨基转移酶（ALT）89U/L（参考范围在 21-72U/L），谷氨酰转移酶（GGT）81U/L（参考范围在 15-73U/L），两种指标轻微的升高，之后经超声检查为局部脂肪变性。由于没有引起如此高水平血氨的病因

”，更需要全社会的共同努力。○ 相关概念 ○纵向科研经费： 

【今日问答】抢救糖尿病酮症酸中毒时，胰岛素用量为？A.4〜6 U/hB.6〜10 U/hC.10〜20 U/hD.20〜30 U/hE.30〜35 U/h解析 :一般采用小剂量（短效）胰岛素治疗方案，即0.1 U/kg·h(成人体重4〜6 U/h)，使血清胰岛素浓度恒定达到100-200μU/ml（选A

【今日问答】抢救糖尿病酮症酸中毒时，胰岛素用量为 ？A.4〜6 U/hB.6〜10 U/hC.10〜20 U/hD.20〜30 U/hE.30〜35 U/h解析 :一般采用小剂量（短效）胰岛素治疗方案，即0.1 U/kg·h(成人体重4〜6 U/h)，使血清胰岛素浓度恒定达到100-200μU/ml（选A

【今日问答】抢救糖尿病酮症酸中毒时，胰岛素用量为 ？A.4〜6 U/hB.6〜10 U/hC.10〜20 U/hD.20〜30 U/hE.30〜35 U/h解析：一般采用小剂量（短效）胰岛素治疗方案，即0.1 U/kg·h(成人体重4〜6 U/h)，使血清胰岛素浓度恒定达到100-200 μU/ml（选A）。大量

【今日问答】抢救糖尿病酮症酸中毒时，胰岛素用量为？A.4〜6 U/hB.6〜10 U/hC.10〜20 U/hD.20〜30 U/hE.30〜35 U/h解析：一般采用小剂量（短效）胰岛素治疗方案，即0.1 U/kg·h(成人体重4〜6 U/h)，使血清胰岛素浓度恒定达到100-200μU/ml（选A）。大量胰岛素

(Columbia)： 148普林斯顿大学(Princeton)： 109洛克非勒大学(Rockefeller U)： 1010康奈尔大学(Cornell)：811耶鲁大学(Yale)：512伊利诺大学(U Illinois, Urbana)：4

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

，我们来花个三五分钟，把胰岛素泵速度调节的精华收入大脑！1. 胰岛素泵怎么配？常规胰岛素 50U＋50 mL 生理盐水，配成胰岛素泵。胰岛素静脉为即刻作用、0.5 h 最强、持续 2 h；皮下为 0.5-1 h 作用、2-4 h 最强、持续 6-8 h。2. 初始速度怎么定？如果既往应用胰岛素<30U/ 天，则为

Prof. Hesham M. Amin University of Texas M.D Anderson Cancer Center, U.S.A.

，CRP 102 mg/L；ESR 89 mm/h；生化：ALB 28 g/L，GLB 34.7 g/L，ALT 109 U/L，AST 54 U/L，GGT...常规正常，CRP 94.2 mg/L，肝功能：ALT 82U/L，AST 42U/L，胃镜检查：胃体溃疡，病理活检未提示恶性肿瘤。予以青霉素抗感染、护肝等治疗后患者仍感乏力

5.14(×109/L)，血红蛋白 129(g/L)，血小板 146(×109/L)，N 3.86(×109/L)，ALT 89(U/L)↑，AST 98...肿痛较前减轻。4 年前（2012 年）患者关节肿痛加重，于我院风湿科住院，化验抗 CCP 抗体 130U/ml、RF 3120IU/mL、ESR 38

(U of T) will be held on Oct 19-21, 2012 in Beijing, China. Aiming to explore