的特异度接近 100%（96～00%），但敏感度仅 50%；EB 病毒阳性提示 PCNSL，其敏感度及特异度分别为 85% 及 98%，但其阳性预测值仅为 29...较前消退（K、L 图）。知识点链接1. 免疫抑制患者出现颅内占位性病变的鉴别诊断很多，临床可根据 CD4 细胞计数进行一一鉴别；2. 弓形虫感染诊断可不依赖活检

Neurol. 4:44.4.Zetterberg, H. and K. Blennow (2015) Mol. Cell. Neurosci. 66:99.5... al. (2001) Thromb. Haemost. 85:63.16.Ewers, M. et al. (2010) Exp. Gerontol.

通过抑制 H+-K+-ATP 酶的活性来发挥作用，而甲氨蝶呤的肾清除是通过氢离子依赖性机制进行的，因此怀疑甲氨蝶呤与奥美拉唑有相互作用，关于相互作用的资料有限... [J]，2012，06（14）：84-85.[2] 郭丰 张宝娣 谢丹青. 奥美拉唑药物相互分析作用. 中国现代药物应用 [J]，2011，5（7

肺癌的发病率和死亡率均居我国恶性肿瘤第 1 位，其中 80%～85% 的患者为非小细胞肺癌（NSCLC）。NSCLC 患者的 5 年生存率约为 15%，约... 融合基因阳性的 NSCLC 患者已经被定义为 NSCLC 的另一种特殊疾病亚型，独立于 EGFR 和 K-rills 等基因的突变而独立存在。中国 NSCLC 患者

、STAT3、和磷酸酰肌醇3-激酶（PI3K）通路，其中包括了细胞转化。除肺癌外，在恶性胶质瘤、胆管癌、胃癌等肿瘤中也发现了这种重排。ROS1重排更多见于NSCLC...持久，疗效持续的中位时间预计为17.6个月；在数据截止时间点，仍有 60％的患者处于治疗期间。 治疗1年后患者的生存率为85％。虽然本研究没有对照组，但这些结果

突变和BRAF V600K突变分别约占转移性黑色素瘤所有BRAF V600突变的85%和10%。因而Mekinist等药物看似前途无限，但是现实的情况是耐药性等

，所以这组病人的也提前脱落了，效果也并不好。随后大家期待的联合组和序贯组的时候，也发现最终得到的结果没有超越，但没有超越也并不意味着失败。遗憾的是，它完成85％剂量的...PI3K/AKT通路？把都阴性的病人丢在一起，做临床研究，是很难获得成功的。ASCO50年的进步对中国事件的影响。比如说，我们应该强调怎样的标准手术程序，哪些能术前

与椎体连接处锯断，沿椎弓根内、外侧壁用K-wires固定。用电子卡尺测量以下指标（单位：mm）：上关节突关节面（SAF）横径，椎弓根横径，上关节突内侧缘、椎骨矢状轴...最宽；VL85%位于SAF中轴线内侧，平均距离为1.36±1.23 mm (95% CI：1.19–1.52)；14.85%位于SAF中轴线外侧，平均距离

EGFR通过磷脂酰肌醇-3 - 激酶（PI3K）/ Akt /雷帕霉素的哺乳动物靶位（ mTOR）的途径进行信号传递，这一通路是细胞生长和增殖，细胞代谢及血管生成...。在一项治疗晚期NSCLC的Ⅱ期临床研究中（N＝85），作为单药治疗，口服mTOR抑制剂依维莫司在约5%的患者中表现出部分缓解，在近50%的

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后，血液流入蛛网膜下腔称为蛛网膜下腔出血（SAH），临床上将 SAH 分为外伤性与非外伤性两大类。非外伤性 SAH[1] 最主要病因为动脉瘤，约占全部病例的 85...初期常无法检测出黄变，故为了避免假阴性的出现建议腰穿在起病 8 小时后执行 [12]。CT/CTA约 85% 的非外伤性蛛网膜下腔出血患者的病因为动静脉

和 α2-抗纤溶酶[6]。此外，原发性出血症状可能与血小板和血管性血友病因子（vWF）紊乱有关。后天性出血性疾病包括维生素 K 缺乏，导致维生素 K 依赖性凝血因子减少[7,8]。目前由于维生素 K 补充剂在出生时广泛使用，这类严重出血并发症的发生率已大大减少。此外新生儿的出血并发症可能与弥散性血管内凝血（继发于脓毒症或缺

;Edition/K6460 液相色谱串联质谱系统结合试剂盒定量分析血液中的同型半胱氨酸案例 2：使用安捷伦 InfinityLCClinicalEdition/K6460 液相色谱串联质谱系统分析血清中的 25-羟基维生素 D

母乳喂养，在老家私人医疗机构出生，是否补充维生素 k1 不详，需进一步完善颅脑 CT。3. 最终明确诊断（1）辅助检查回报颅脑 CT 提示脑室内出血。（2）最后诊断晚发性维生素 k 缺乏症并颅脑出血（3）治疗立即补充维生素 K1、输血浆改善出血症状，输血纠正贫血。适当使用甘露醇减低颅高压；其他对症支持治疗及神经外科协助诊治

，为您揭晓耳机与听力之间的秘密。避免耳机危害，一定要记住这些喔耳机的音量输出一般在 85 至 110 分贝。耳朵暴露在 85 分贝以上的音量里 8 小时，或 100 分贝以上的音量里 15 分钟都是不安全的。如果耳机音量超过 85 分贝、佩戴时长超过 30 分钟，可能引起暂时性听力下降；如果音量超过 85 分贝

The 9th International Bioinformatics Workshop (IBW2011)
July 11-13, 2011. Xi’an, China
Announcement for Papers
（Submission deadline: April 15, 2011）

Sponsored by:
Committee of Tumor Marker, Chinese Anti-Cancer Association
Medical & Health Engineering Division of the Chinese Academy of Engineering
Organized by:
The Cell Engineering Research Center, Fourth Military Medical University
The School of Biomedical Engineering, Fourth Military Medical University
Co-organized by:
Medical & Health Engineering Division of the Chinese Academy of Engineering
Sponsored by:
National Science Foundation of China
FourthMilitary Medical University
Ministry of Education, China.
Workshop Website:
http://ibw2011.fmmu.edu.cn
Welcome Message
The International Bioinformatics workshop (IBW) series aims to promote scientific communication for Chinese researchers on the cutting-edge progress in bioinformatics, computational and systems biology, genomics, and proteomics. As a major annual event in the Chinese bioinformatics community, the workshop series have attracted over 2,000 students and postdoctoral fellows in 8 previous successful meetings, which took place at Fudan University (2003), Tsinghua University (2004), Jilin University (2005), Central South University (2006), Shandong University (2007) and Yunnan University (2008), Soochow University (2009), and Wuhan University (2010), respectively.
IBW2011, organized by the Cell Engineering Research Center and the School of Biomedical Engineering, Fourth Military Medical University, co-organized by the Chinese Academy of Engineering, will be held from July 11th to 13th, 2011, in Xi'an, China. The workshop is sponsored by NSFC, FMMU, and by the Ministry of Education, China. About 20 speakers from both domestic and overseas have agreed to present at the workshop.
Xi’anis one of the most attractive historical cities. Strolling in street of city, one will get the feeling of walking through a big historical museum, in which one can witness the Eighth Wonder in the world- “terra-cotta warriors and horses” of Qin dynasty, the Big and Small Wild Goose Pagodas of Tang dynasty and the city wall of Ming dynasty. We believe that our kind receptions will make this trip a colorful and unforgettable one for you.
Looking forward to meeting you in Xi’an on July 11th -13th, 2011.
Yours faithfully,
Chairman: Zhinan Chen, Ph.D.
Ying Xu, Ph.D

Conference organization

Honorary Chair：	Prof. Daiming Fan	President, Fourth Military Medical University Academician, the Chinese Academy of Engineering (CAE)
Chair:	Prof. Zhinan Chen	Academician, the Chinese Academy of Engineering (CAE) The Fourth Military Medical University, China
	Prof. Ying Xu	GeorgiaUniversity, IBW steering committee member

Program committee:

Chair:	Qian Wang	FourthMilitary Medical University
Co-chair:	Yingming Feng	FourthMilitary Medical University
Secretary:	Jinliang Xing	FourthMilitary Medical University
Member:	Luonan Chen	Shanghai Institute of Biological Sciences, CAS
	Runsheng Chen	Instituteof Biophysics, CAS
	Yuan Gao	Virginia Commonwealth University, USA
	Jingdong Han	CAS-MPG Partner institute for Computational Biology
	Bailin Hao	FudanUniversityand Institute of Theoretical Physics, CAS
	Tao Jiang	Universityof California at Riverside, USA
	Hoong-Chien Lee	National Center University, Taiwan
	Ming Li	University of Waterloo, Canada
	Juan Liu	WuhanUniversity
	Youyong Lv	Beijing University/School of Medicine
	Zhengsu She	BeijingUniversity
	Yu Shyr	Vanderbilt University, USA
	Zhirong Sun	TsinghuaUniversity
	Haixu Tang	Indiana University, USA
	Wen Wang	Kunming Institute of Zoology, CAS
	Stephen Wong	Methodist Hospital Research Institute, USA
	Weixiong Zhang	Washington University, USA
	Xuegong Zhang	TsinghuaUniversity

Steering Committee:

Chair:	Ying Xu	Universityof Georgia
Co-chair:	Liping Wei	BeijingUniversity
	Yixue Li	Shanghai Center for Bioinformatics Technology
	Xiaole Shirley Liu	HarvardUniversity

Organizing committee:

Chair:	Wenbin Li	FourthMilitary Medical University
Co-chair:	Yong Ji	FourthMilitary Medical University
Secretary:	Hongbing Lu	FourthMilitary Medical University
Member:	Dongguang Wang	FourthMilitary Medical University
	Ruian Wang	FourthMilitary Medical University
	Huijie Bian	FourthMilitary Medical University
	Jianli Jiang	FourthMilitary Medical University
	Chun Jiao	FourthMilitary Medical University

1. Workshop Scope:

The workshop will cover the top subjects on computational genomics, computational proteomics, computational systems biology and biological data mining. Submissions of summaries describing original work in, but not limited to, the following topics are encouraged.
1. Computational genomics
2. Bio-sequence analysis
3. Comparative genome analysis
4. Biological networks
5. Computational proteomics
6. Computational structural biology
7. Computational systems biology
8. Biological data mining
9. Computational evolutionary biology
10. Algorithmic and combinatorial methods in bioinformatics.
11. Disease genomics and proteomics

II. Call for summaries and speakers
We are now open to accept contributed talks for all areas in bioinformatics including but not limited to the conference topics. Please e-mail us your intention and a summary of paper to be spoken at the conference and submit your self-introduction for review and evaluation. All submissions will be peer-reviewed by experts in the field independently based on originality, significance, quality and clarity. Authors should format their papers (less than 4-pages) and submit requested files to the workshop mailboxapctbm2009@163.com. Mailing papers are not welcome.
Important deadlines:
Paper submission deadline: May 15, 2011
Notification of paper acceptance deadline: May 30, 2011

III. Rules for Papers (All papers should be organized as following rules):
(1). All Papers (abstract or full text) must be submitted as an unpublished presentation. They must be written in English with Word format to fit into the A4 layout.
(2). Styles of English text are as the followings:
﹡Text format: Times New Roman of 11 pt, single spaced.
﹡Title: Simple and clear, all in capital letter and not bold.
﹡Author has no title name, the first letter capitalized, aligned on the left ( the first name before surname, example: Li Xiangyang is Xiangyang Li ).
﹡Organization, city and country are aligned on the left.
﹡Paper is composed of the followings: Objectives, methods, results, conclusions.
﹡Please be sure to carefully check your paper for content errors, spelling, names, etc, before submitting. We are not able to proofread for or correct spelling, typographical, grammatical, or scientific errors.





IV. Conference Program

DragonStar Course	July 4th	Registration & Picking up course handouts
	July 5th	Morning	Opening Ceremony
			Course Session
		Afternoon	Course Session
	July 6th-10th	All day	Course Session with Projects
IBW2011 Workshop	July 10	All day	Registration
	July 11th	Morning	Opening Ceremony
		Afternoon	Plenary Session
		Evening	Welcome Banquet
	July 12th	All day	Plenary Session
	July 13th	Morning	Plenary Session and Closing Ceremony

V. Invited Speakers:
1、Luonan Chen, Shanghai Institute of Biological Sciences
（陈洛南教授，中科院上海生命科学研究所）
2、Runsheng Chen, Institute of Biophysics, CAS
（陈润生院士，中科院生物物理研究所, 中国科学院院士）
3、Yuan Gao, Virginia Commonwealth University, USA
（高原教授，弗吉尼亚州立邦联大学，美国）
4、Jingdong Han, CAS-MPG Partner institute for Computational Biology
（韩敬东研究员, 中科院遗传与发育生物学研究所）
5、Bailin Hao, Fudan University and Institute of Theoretical Physics, CAS
（郝柏林院士,中科院理论物理研究所，中国科学院院士）
6、Tao Jiang, University of California at Riverside，USA
（姜涛教授，美国加州大学河滨分校）
7、Hoong-Chien Lee, National Center University, Taiwan
（李弘謙教授，国立中央大学，台湾）
8、Ming Li, University of Waterloo, Canada
（李明教授，加拿大滑铁卢大学）
9、Yixue Li, Shanghai Bioinformatics Center，CAS
（李亦学研究员，中国科学院上海生命科学研究院生物信息中心）
10、Xiaole Liu, Harvard University and Tongji University
（Xiaole Liu教授，哈佛大学，同济大学）
11、Youyong Lv, Peking University School of Medicine
（吕有勇教授，北京大学临床肿瘤学院）
12、Zhensu She, Peking University
（佘振苏教授，北京大学）
13、Yu Shyr, Vanderbilt University, USA
（石瑜教授，范德堡大学，美国）
14、Zhirong Sun, Tsinghua University
（孙之荣教授, 清华大学生物科学与技术系 ）
15、Haixu Tang, Indiana University, USA
（唐海旭教授，印第安纳大学，美国）
16、Wen Wang, Kunming Institute of Zoology, CAS
（王文研究员，中科院昆明动物研究所，973首席科学家 ）
17、Liping Wei, Peking University
（魏丽萍教授，北京大学生命科学院 ）
18、Stephen Wong, Methodist Hospital Research Institute, USA
19、Jinliang Xing, The Four Military Medical University
（邢金良教授，第四军医大学细胞工程研究中心）
20、Ying Xu, University of Georgia and Jilin University
（徐鹰教授，乔治亚大学，吉林大学长江学者特聘教授）
21、Weixiong Zhang, Washington University
（Weixiong Zhang教授, 华盛顿大学）
22、Xuegong Zhang, Tsinghua University
（张学工教授, 清华大学生物信息学主任 ）

VI. Registration
Registration for the workshop is free and open to the public. To register for the workshop, please complete the registration form available online at website:http://ibw2011.fmmu.edu.cn, and send the registration form to mailbox ibw2011@fmmu.edu.cn. All registrations will be confirmed by email.
Important dates:
Registration deadline for DragonStar course: May 15, 2011
Registration deadline for the workshop: June 10, 2011

VII. Conference Accommodation Information:
To facilitate the accommodation and make the participation more convenient, we provide the following optional services including lodging and meals that will be charged. Please identify which service you need when you fill the registration form. The reimbursable receipt could be issued for all related payments.
Hotel service: Regular participants need to pay for the hotel fee. The reservation fee of 200RMB is required for each reservation. The conference has arranged two hotels below to choose:A.Xi’an Jianguo Hotel （★★★★）Location: No.2, Huzhu Street, Xi’an City, Shaanxi Province, China
Website: http://www.hotelxianjianguo.com
Tel：86-29-82598888;
Conference room rate：

Jianguo Hotel （★★★★）	Standard Room	Deluxe Room	Executive Suite
	Single/double	Single/double
	￥430/night	￥530/night	US$ 180/night

All room rates include 15% service charge.
B. The Fourth Military Medical University Hotel
Location: No.169, Changlexi Street, Xi’an City, Shaanxi 710032, China
Tel：86-29-84775888
Conference room rate：

The Fourth Military Medical University Hotel	Standard Room	Deluxe Room
	Single/double	single/double
	￥170/night	￥380/night

2. Conference Documents (optional):
150 RMB per copy for 5-day DragonStar course;
200 RMB per copy for 3-day workshop.
Each copy contains the teaching materials required by the course, materials of all invited and contributed talks, the abstracts of all potential accepted papers, a conference programme, a workshop badge, and so on.
3. Meal Tickets (optional):
450 RMB per set for DragonStar course (consists of tickets for five-day meals from Jul.6-10)
600 RMB per set (consists of tickets for four buffet meals and one banquet from July 11 to 13).
Please note that the meal set is nonseparable.

VII. Conference Language: English/Chinese

IX. Contact information:
Questions or comments on the conference:
Contact Person: Professor Lu
Tel: 86-29-84774837, 13572116125
Email:luhb@fmmu.edu.cn
IBW2011@fmmu.edu.cn

Questions or comments on paper submission:
Contact Person:Miss Cheng
Tel: 86-29-84772286
Email:apctbm2009@163.com

Questions or comments on registration:
Contact Person: Teacher Wang
Tel: 029-84774840-802,
Email:IBW2011@fmmu.edu.cn
Fax: 86-29-84774837

Address: The Cell Engineering Research Center/School of Biomedical Engineering
FourthMilitary Medical University,
169 Changlexi Rd, Xi’an, Shaanxi 710032, China.
Website: http://ibw2011.fmmu.edu.cn

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