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2012.09.19 北京蛋白质组研究中心 第三期蛋白质组学技术与应用高级培训班

北京蛋白质组研究中心
第三期蛋白质组学技术与应用高级培训班
（第三轮通知）
报到时间、地点：
外地学员请于7月18日13:30-21:00，在北京扬子江海燕药业海诺康会馆（中关村生命科学园内）大堂办理报到手续。地址：北京市昌平区科学园路16号（从生命科学园区大门向北约50米见丁字路口左转约200米，扬子江海燕药业院内，与北京蛋白质组研究中心隔湖相望）。由于园区位置距离市区较远，晚上报到的学员请注意提前自行准备晚餐。
本地学员请于7月19日8:30前在北京蛋白质组研究中心一楼1107室办理报到手续。地址：北京市昌平区科学园路33号（从生命科学园区大门向北约50米见丁字路口右转约150米，路西三层暗红色楼，上写“Proteome”）。
住宿安排：
需住宿人员直接到海诺康会馆办理住宿手续，每个标准间可住两位代表，298元/天/间。海诺康会馆电话：010-80728999。
报到流程：
签到、交费、领资料（包括讲义、餐券、代表证、笔）。20日下午茶歇时间，领取会议发票。
上课地点：北京蛋白质组研究中心多功能厅1109室。
日程安排：
时 间内 容授课专家
7月19日
（1109室）		9:00-10:00蛋白质组学理论策略与应用钱小红
10:00-11:00蛋白质组研究中的样本制备技术姜 颖
11:00-11:10茶歇
11:10-12:10蛋白质组学研究中的分离技术张养军
12:10-13:10午餐
13:10-14:10生物质谱及其在蛋白质组研究中的应用蔡 耘
14:10-15:10蛋白质组信息学朱云平
15:10-15:20茶歇,
15:20-16:20定量蛋白质组学研究方法与应用应万涛
16:20-17:20学员合影，参观BPRC实验室
7月20日
（1109室）		9:00-10:00定量蛋白质组学研究中的实验设计徐 平
10:00-11:00蛋白质相互作用研究技术与应用王 建
11:00-11:10茶歇
11:10-12:10蛋白质相互作用数据分析李 栋
12:10-13:10午餐
13:10-14:10多肽组学技术与应用魏开华
14:10-15:10蛋白质组学前沿与热点秦 钧
15:10-15:30茶歇，领发票
15:30-16:40讨论、答疑
16:50-17:00发证书，交调查表
7月21日、
22日		9:00-12:00

13:30-16:50		二维荧光差异凝胶电泳技术(2DE-DIGE)-1126
色谱分离技术—1142里间
MALDI TOF/TOF质谱仪操作使用--1132
液质联用质谱仪鉴定蛋白--1136
就餐安排：7月19-22日
早餐：7:30-9:00，海诺康会馆一楼宴会厅，住宿含早餐券
午餐：12:10-13:10，北京蛋白质组研究中心多功能厅1107室
晚餐：17:30-18:30，北京蛋白质组研究中心多功能厅1143室

报到及住宿酒店位置：
提示：如需乘做出租车，请随身携带路线图，以便指引司机。
北京中关村生命科学园地址：北京市海淀区北清路
扬子江药业集团海诺康会馆位置：北京市昌平区生命科学园路16号（从生命科学园区大门向北约50米见丁字路口左转约500米即到）
中关村生命科学园交通路线图：

乘车路线：
1、从北京站：从北广场出站乘地铁2号线至“西直门”站下车，换乘城铁13号线至“西二旗”站下车，出站后换521路至“生命科学园”站或乘出租车至生命科学园扬子江药业集团海诺康会馆（车费约16元）；从北京站直接乘坐出租车至中关村生命科学园约30公里。
2、从北京西站：从北广场出站乘320路或特6路至“中国农科院”站下车，换乘运通205路至“生命科学园”站；从北京西客站直接乘坐出租车至中关村生命科学园约30公里。
3、从首都机场：乘坐机场大巴到“中关村二桥”站下车，换乘出租车直接到中关村生命科学园（约18公里），或者下车后在公交车站“中关村南站”乘运通205路到“生命科学园”站；或从机场直接乘坐出租车至中关村生命科学园（约37公里）。
4、北京市内：建议乘坐乘铁13号线至西二旗站下车，出站后换521路至“生命科学园”站或换乘出租车至生命科学园扬子江药业集团海诺康会馆（车费约18元）。
自驾车路线：市区经八达岭高速---北安河出口（九号）下高速---辛庄桥下左转向西---沿北清路直行约1.5公里见生命科学园---入园后约50米到丁字路口左转约200米即到。
其他问题请联系：
电话：周建平（010）80705277 史冬梅（010）80705888
传真：（010）80705155
电邮：sky_proteomics@sina.com
地址：北京市昌平区科学园路33号（102206）
再次感谢大家的参与，祝大家北京之行愉快！
北京蛋白质组研究中心
蛋白质组学国家重点实验室
中国生物化学与分子生物学会蛋白质组学专业委员会
2011-6-25
Beijing Proteome Research Center
The 3rd Advanced Training Workshop in the Technology and Applications of Proteomics
Proteomics is revealing the secret of life and has found wide applications in all disciplines of life science. It is becoming the frontier and breakthrough point in life science and biotechnology in the 21st century. To further facilitate the development of proteomics in China, Beijing Proteome Research Center (BPRC), State key Laboratory of Proteomics (SKLP) and China Human Proteome Organization (CNHUPO) will hold jointly the 3rd Advanced Training Workshop in the Technology and Applications of Proteomics from July 19 to 22, 2011 in Zhongguancun Life Science Park.
BPRC was founded in 2004. It hosts the main body of the SKLP and is the executive headquarter of the International Human Liver Proteome project (HLPP). BPRC is the leader of Chinese proteomics research and has established an internationally renowned research platform for modern proteomics. Many national projects of the 973 and 863 Plans, the Chinese human liver proteome project, and projects funded by the National Natural Science Foundation (in total of more than 100 projects) have been and are being carried out in BPRC.
This training workshop will be taught by experts from BPRC who have been working on the forefront of proteomics research. Lectures on “Technology and Methodology for Proteomics, Technology know-how and Experimental Design, Frontiers and Hot Topics in Proteomics Research” will be given on July 19 and 20. On July 21 and 22, trainees will watch live demonstrations of key proteomics techniques. A certificate of completion of the training in proteomics will be issued for all participants.
1、 Training Syllabus
Lectures
Theory, Strategy and Application of Proteomics Dr Xiaohong Qian
Sample Preparation in Proteomics Dr Ying Jiang
Separation Technology in Proteomics Dr Yangjun Zhang
Biological Mass Apectrometry and Application in Proteomics Yun Cai
Bioinformatics in Proteomics Dr Yunping Zhu
Methods and Applications of Quantitative Proteomics Dr Wantao Ying
Experimental Design in Quantitative Proteomics Dr Ping Xu
Techniques and Applications of Protein-Protein Interactions Dr Jian Wang
Data Analysis of Protein-Protein Interactions Dr Dong Lee
Technology and Application of Pepdomics Dr Kaihua Wei
Frontiers and Hot Topics in Proteomics Dr Jun Qin
Tour of BPRC
Experimental Demonstration (half a day per item)
1) 2DE-DIGE
Different protein samples are labeled with fluorescent dyes of two different colors so that they can run together in gel electrophoresis. This reduces the experimental error, increases sensitivity and the dynamic range of the detection. The software package can automatically detect proteins of differential expression. This method is suited for differential proteomics of multiple samples with large differences in protein expression among individual samples.
2) Techniques in Chromatography
Analytical high efficiency liquid chromatography, capillary high efficiency liquid chromatography, and their in-line use with mass spectrometry will be discussed. Emphases will be given on the components of liquid chromatography, the basic functions of the various components, basic operation and handling of the liquid chromatography, potential problems and trouble shooting in the operation of liquid chromatography. After the lecture, you should have a basic understanding of liquid chromatography and its use in separation of peptides and proteins.
3) Operation of a MALDI TOF/TOF Mass Spectromter
We will teach you how to: desalt the sample, prepare the matrix solution, apply samples, set parameter and check hardware, generate and edit the sample table, control the laser, manually acquire data, automatically acquire data in a batch mode, calibrate the instrument, smoothen and correct background, label peaks, use the DataExplore software, operate the mass spectrometer, export data, maintain database, and perform routine instrument maintenance.
After the session, you should have a basic idea of how to use MALDI-TOF/TOF mass spectrometry.
4) Protein identification with an in-line liquid chromatography electro-spray mass spectrometry (LC-ESI-MS)
The technique of LC-ESI-MS/MS is the method of choice for the identification of proteins. It is well suited for complex mixture of peptides. The working horse in the field is capillary reverse phase liquid chromatography, coupled with a Nano-spray source, in-line with a liner Ion Trap mass spectrometer (LTQ). Such combination has proven to be efficient and accurate, and it can be used to identify proteins continuously with high sensitivity. We will cover the keys to optimized protein identification techniques in this session: the condition for best HPLC separation and parameter settings for mass spectrometry, as well as parameter settings for data base search.
2、 Logistic Details
1) A certificate issued by BPRC and SKLP will be presented at the end of the workshop.
2) BPRC is certified by ISO/IEC 17025(CNAS-CL01), and provides scientific and technological services in research and development for academics and industries alike. As a participant of this training workshop, you are eligible to obtain these services with favorable pricing. Please visit our website:
www.bprc.ac.cn/guidance/list.php?catid=27 for details.
3) As a participant of this training workshop, you are also eligible to purchase a product from Beijing C&N International Sci-tech Co., Ltd. at a discount. Please visit the websites for details:
3、Time and Place
On-site registration:
July 18, 13:30 to 21:00, Beijing Yangtze River Pharmaceutical Group, Hainuokang Guild Hall（No.16, Lifee Park Road, Changping District, Beijing,China）
July 19，8:30-10:00, BPRC (No.33, Science Park Road, Changping District, Beijing,China）
Training Session:
July 19 to 22, BPRC.
4、Registration and Fees
Online Registration:
Advanced Registration: June 17, 2011
The registration includes meeting fee, training material, and food. Food and accommodation are arranged by the organizer. Accommodation is an extra. Please fill in the information online if you need accommodation arrangement.
Workshop Tuition:
（1）Lecture
￥1300 (￥1100 for students), if you register before June 17, 2011.
￥1400 (￥1200 for students), if you register between June 18 and July 19, 2011.
（2）Experimental Demonstration
￥650/item/half day (￥450 for students) if you register before June 17, 2011.
￥700/item/half day (￥500 for students) if you register between June 18 and July 19, 2011.
Student ID is required for student discount.
5、Payment
Account Number：0200004909200041055
Name of Account：Beijing Proteome Research Center (BPRC)
Bank：Industrial and Commerce Bank of China, Beijing Yongding Road Branch
Note: please write clearly your name and place of work when wiring the payment. Pay to “Training Workshop of Proteomics”. Please fax your receipt of fund wiring to BPRC, or e-mail a scanned PDF to sky_proteomics@sina.com.
6、Contacts
Contact Person and Phone：
Registration：Ms. Jianping Zhou 86-10-80727777-1512
Information： Ms. Dongmei Shi 86-10-80727777-1520, 86-10-80705888
Fax：86-10-80705155
E-mail：sky_proteomics@sina.com
Mailing Address：No.33, Science Park Road, Changping District, Beijing, 102206, China
Beijing Proteome Research Center
State key Laboratory of Proteomics
China Human Proteome Organization
May 9, 2011

2012.09.19 医院精细化管理高层研讨会（2011年1月15日，无锡）

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上海·2012年5月21-23日尊敬的老师，您好！生理药代动力学模型（PBPK）在药物研发与监管中得到广泛应用意味着新时代的来临！它改变了动物试验和人体实验传统研究模式流程，指导制药企业项目决策及效率提高；FDA和EMA的使用及推荐，促使国外制药企业及学术单位相关研究者都在学习及掌握PBPK的应用。为促进我国在该领域的发展，力争与全球同步，凡默谷特邀美国Simulations Plus顶尖专家来华授课，让您了解及掌握PBPK知识、获悉国外最新应用、亲授多年使用经验，授课过程将以理论与实践相结合的形式进行。GastroPlus是由美国Simulations Plus公司研发的基于机制性生理模型的药代动力学、药效动力学(PBPK/PD)模拟软件，目前在FDA和几乎所有的全球顶尖制药公司中得到广泛应用，被誉为同类软件中的“黄金标准”。为确保培训效果，限额50人/班，第一轮通知发出后，已得到广大中国用户的积极响应和踊跃报名。报名从速！为何本次GastroPlus Workshop值得您参加？1）药物研发及监管中争相应用PBPK模型的时代已经来临！2）PBPK辅助药物研究可方便指导项目决策、节约成本、缩短时间；3）FDA已广泛采用PBPK模拟来制定法规和对新药及仿制药进行审批；4）FDA及各大制药企业对全球最权威的PBPK模拟软件GastroPlus倍加青睐；5）零距离接触Simulations Plus首席科学家，并参与学习的最新应用案例；6）您可免费获得一个月的GastroPlus软件试用。本次GastroPlus Workshop将让您受益良多：1）制药企业或CRO：有利于您理解您的客户或其他Sites实验方案设计思路、下一阶段决策及实验开展、合理设计实验方案；2）学术研究：启示您开辟新的药代、药剂等研究方向，剖析药物作用机制等；3）临床药理研究：合理设计临床试验方案，不同人群PK/PD研究等；4）法规部门：协助制定新药及仿制药政策和标准。报名方法：请您填写报名回执，并通过Email的方式反馈给我们。Email: training@pharmogo.com报名截止：2012年4月20日(北京培训班)/2012年4月30日(上海培训班)联系人：周伟,电话：021-61638583-8001报名确认：1）报名确认以凡默谷收到款项或报名者提供汇款凭证为准，凡默谷可先提供发票以供报销；2）会务组在接到报名后，将email或电话通知学员培训班相关事项。温馨提醒：学员必须自带已安装好Gastroplus程序的电脑参加培训，现场不提供电脑。

GastroPlus Workshop Course Instructors List

Michael B. Bolger

Chief Scientist

Simulations Plus Inc.

Dr. Bolger is Chief Scientist at Simulations Plus, he oversees a team of scientist / programmers at Simulations Plus, Inc. (Lancaster, CA) in the development of software programs (ADMET Predictor/Modeler, MedChem Studio/Designer, GastroPlus, DDDPlus, and MembranePlus) for estimation of biopharmaceutical properties, simulations of absorption and bioavailability, automated generation QSP/AR model building, in vitro dissolution, and cell culture permeability simulation.

As a faculty member at USC School of Pharmacy, his research was supported by several NIH basic science research grants and he published over 50 peer-reviewed publications. From 1989-1991 he served as a FDA National Science Advisor. He has served as a reviewer for numerous scientific publications. He is currently Adjunct Associate Professor of Pharmaceutical Sciences at USC.

Haiying Zhou, Ph.D.

Senior Scientist II

Simulations Plus Inc.

Dr. Zhou is Senior Scientist II at Simulations Plus, she focused on the development of modeling and simulation software for quantitative understanding of the pharmacokinetics and pharmacodynamics of drug candidates (GastroPlus), in vitro dissolution of active pharmaceutical ingredients and formulation excipients under various experimental conditions (DDDPlus).

She received her M.S. degree in automation from East China University of Science and Technology (ECUST) in 2002 and her Ph.D in Biomedical Engineering from Case Western Reserve University (CWRU) in 2009. Her research interests in CWRU include multi-scale mathematical modeling of gas transport and cellular metabolism with emphasis on the metabolic regulation during different conditions, e.g. hypoxia and exercise.

John DiBella

Vice President of Marketing Simulations Plus Inc.

John DiBella is the Director – Marketing & Sales at Simulations Plus, He joined Simulations Plus in 2003 and has spent time working on the development of GastroPlus? and DDDPlus? software and consulting projects. Now, he leads the marketing & sales activities for the company while continuing to travel the world hosting training seminars.John obtained B.S. and M.S. degrees (with honors) in Biomedical Engineering from Case Western Reserve University in 2003. His graduate research was focused on computational modeling of physiological systems.

培训班详情：请下载附件参加北京培训班请点击下载：GastroPlus北京培训班第二轮通知/BeiJing GastroPlus-Intro-Workshop 2nd Notice参加北京培训班请点击下载：GastroPlus上海培训班第二轮通知/ShangHai GastroPlus-Intro-Workshop 2nd Notice

2012.09.19 首届中国PBPK模拟软件GastroPlus Workshop第二轮通知

首届中国PBPK模拟软件GastroPlus Workshop第二轮通知

北京·2012年5月16-18日

上海·2012年5月21-23日尊敬的老师，您好！生理药代动力学模型（PBPK）在药物研发与监管中得到广泛应用意味着新时代的来临！它改变了动物试验和人体实验传统研究模式流程，指导制药企业项目决策及效率提高；FDA和EMA的使用及推荐，促使国外制药企业及学术单位相关研究者都在学习及掌握PBPK的应用。为促进我国在该领域的发展，力争与全球同步，凡默谷特邀美国Simulations Plus顶尖专家来华授课，让您了解及掌握PBPK知识、获悉国外最新应用、亲授多年使用经验，授课过程将以理论与实践相结合的形式进行。GastroPlus是由美国Simulations Plus公司研发的基于机制性生理模型的药代动力学、药效动力学(PBPK/PD)模拟软件，目前在FDA和几乎所有的全球顶尖制药公司中得到广泛应用，被誉为同类软件中的“黄金标准”。为确保培训效果，限额50人/班，第一轮通知发出后，已得到广大中国用户的积极响应和踊跃报名。报名从速！为何本次GastroPlus Workshop值得您参加？1）药物研发及监管中争相应用PBPK模型的时代已经来临！2）PBPK辅助药物研究可方便指导项目决策、节约成本、缩短时间；3）FDA已广泛采用PBPK模拟来制定法规和对新药及仿制药进行审批；4）FDA及各大制药企业对全球最权威的PBPK模拟软件GastroPlus倍加青睐；5）零距离接触Simulations Plus首席科学家，并参与学习的最新应用案例；6）您可免费获得一个月的GastroPlus软件试用。本次GastroPlus Workshop将让您受益良多：1）制药企业或CRO：有利于您理解您的客户或其他Sites实验方案设计思路、下一阶段决策及实验开展、合理设计实验方案；2）学术研究：启示您开辟新的药代、药剂等研究方向，剖析药物作用机制等；3）临床药理研究：合理设计临床试验方案，不同人群PK/PD研究等；4）法规部门：协助制定新药及仿制药政策和标准。报名方法：请您填写报名回执，并通过Email的方式反馈给我们。Email: training@pharmogo.com报名截止：2012年4月20日(北京培训班)/2012年4月30日(上海培训班)联系人：周伟,电话：021-61638583-8001报名确认：1）报名确认以凡默谷收到款项或报名者提供汇款凭证为准，凡默谷可先提供发票以供报销；2）会务组在接到报名后，将email或电话通知学员培训班相关事项。温馨提醒：学员必须自带已安装好Gastroplus程序的电脑参加培训，现场不提供电脑。

GastroPlus Workshop Course Instructors List

Michael B. Bolger

Chief Scientist

Simulations Plus Inc.

Dr. Bolger is Chief Scientist at Simulations Plus, he oversees a team of scientist / programmers at Simulations Plus, Inc. (Lancaster, CA) in the development of software programs (ADMET Predictor/Modeler, MedChem Studio/Designer, GastroPlus, DDDPlus, and MembranePlus) for estimation of biopharmaceutical properties, simulations of absorption and bioavailability, automated generation QSP/AR model building, in vitro dissolution, and cell culture permeability simulation.

As a faculty member at USC School of Pharmacy, his research was supported by several NIH basic science research grants and he published over 50 peer-reviewed publications. From 1989-1991 he served as a FDA National Science Advisor. He has served as a reviewer for numerous scientific publications. He is currently Adjunct Associate Professor of Pharmaceutical Sciences at USC.

Haiying Zhou, Ph.D.

Senior Scientist II

Simulations Plus Inc.

Dr. Zhou is Senior Scientist II at Simulations Plus, she focused on the development of modeling and simulation software for quantitative understanding of the pharmacokinetics and pharmacodynamics of drug candidates (GastroPlus), in vitro dissolution of active pharmaceutical ingredients and formulation excipients under various experimental conditions (DDDPlus).

She received her M.S. degree in automation from East China University of Science and Technology (ECUST) in 2002 and her Ph.D in Biomedical Engineering from Case Western Reserve University (CWRU) in 2009. Her research interests in CWRU include multi-scale mathematical modeling of gas transport and cellular metabolism with emphasis on the metabolic regulation during different conditions, e.g. hypoxia and exercise.

John DiBella

Vice President of Marketing Simulations Plus Inc.

John DiBella is the Director – Marketing & Sales at Simulations Plus, He joined Simulations Plus in 2003 and has spent time working on the development of GastroPlus? and DDDPlus? software and consulting projects. Now, he leads the marketing & sales activities for the company while continuing to travel the world hosting training seminars.John obtained B.S. and M.S. degrees (with honors) in Biomedical Engineering from Case Western Reserve University in 2003. His graduate research was focused on computational modeling of physiological systems.

培训班详情：请下载附件参加北京培训班请点击下载：GastroPlus北京培训班第二轮通知/BeiJing GastroPlus-Intro-Workshop 2nd Notice参加北京培训班请点击下载：GastroPlus上海培训班第二轮通知/ShangHai GastroPlus-Intro-Workshop 2nd Notice
从历史发展看磷结合剂的变迁

2015.11.24 从历史发展看磷结合剂的变迁

我们不得不「三思而后行」。那么，使用磷结合剂治疗时如何尽可能地避免风险？本文结合 2014 年意大利学者 Locatelli F 在 Expert Opin...: 10.1681/asn.2008060609.3. Locatelli, F., et al., Phosphate binders for the treatment

2012.09.19 2012中德国际脊柱微创高峰论坛

。会议交通路线地址: 济南市济齐路22号(济南锅炉厂南行50米)乘车路线: 乘坐83、45、2、K100、K59路到交校路下车北行500米；乘坐

2012.09.19 2012年第12届印度国际生物技术展览会

印度最大的生物技术展！预计到2030年，世界人口将达到83亿，其中97%的增长发生在发展中国家。人口的增长将给自然资源带来巨大的压力。然而生物技术为许多医疗和资源运用方面的问题带来了解决的曙光。生物技术已经运用到医疗保健、工业和农业，成为一项前途光明的新兴产业。生物技术经济同时也为这些国家贡献了不少的

2013.03.18 2013年基金委与英皇家学会合作项目名单公布

of Dundee24F...25F030402研究新的计算神经

2012.09.19 中英再生医学高峰论坛

主席：Prof. Z. F. Cui (崔占峰 教授 )与会专家：英 方 专 家Experts of UK Z. F. CUI... and challenges Z. F. CUI10:35-10:45 Discussion10:45-10:55 Break

2010.06.27 2010年第三届南方急危重症论坛议程

相约羊城，热切期盼，携手并进，共同参与！附件：F:\科室资料\2010年第三届南方急危重症论坛议程.ppt
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