，它对肿瘤起着抑制或促进的作用，取决于其表达的细胞类型及其所处的环境。TGF-β通过异源四聚体受体复合物传递信号，这个受体复合物是由两个I型和两个II型的跨膜丝氨酸/苏氨酸激酶受体组成的。与配体结合后，II型受体(TGF-β RII)将I型受体(TGF-β RI)磷酸化；因为I型受体表达的种类

朱凤才教授接受丁香园专访本期微访谈，丁香园特邀江苏省疾病预防控制中心副主任朱凤才教授与大家一起探讨“中国疫苗临床试验的现状与发展”这一话题。欢迎大家踊跃参加，提问请戳：http://i.dxy.cn/talk/vaccine传染性疾病最主要的控制手段就是预防

ACE2缺乏致血管功能减退血管紧张素II产生氧化应激和脑动脉内皮功能不全，血管紧张素II的I型受体可能在寿命及血管衰老中起到作用。血管紧张素转化酶2型（ACE2）将血管紧张素II转化为血管紧张素（1-7），并可对血管紧张素II的效应起保护作用。美国爱荷华州大学的Ricardo A. Pena

（丁香园通讯员7月10日讯）近日，由南京医科大学主办的综合性医药类期刊《JournalofBiomedicalResearch》（即《生物医学研究杂志》，以下简称：JBR）入驻丁香客（官方主页：http://i.dxy.cn/jbr）。据悉，在入驻丁香客后，JBR将为网友

习班”(I类继续教育学分6分，项目编号：2015-05-01-096 )暨2015年省级继续教育项目“保留(保护)器官功能的妇科微创手术研讨会”(I类继续教育学分4分，项目编号：2015-05-05-01010 ) 将于2015年9月10日-13日在广东省广州市召开。本次会议将邀请国内在妇科微创

男性 5 例，女性 6 例，年龄 44-72 岁。使用的肉毒毒素为德国生产的 Xeomin/NT201，经灭菌生理盐水稀释成 100u/2 ml，注射剂量均低于 12u/kg。在注射前 24 小时和注射后 10 天分别进行 30 分钟的心电图监测。结果发现，肉毒毒素注射前和注射后的 HRV 线性和非线性变化差异均无统计学意义

-34A randomized pilot phase I study of modified CEA peptide...A randomized pilot phase I study of modified CEA peptide (CAP1_6D)&

病毒，包括白血病和神经系统疾病。FDA在一份声明中说，Avioq公司的HTLV-I/II Microelisa系统是现在唯一可以用来筛选献血中两类人类T淋巴细胞...HTLV病毒检测，为血液机构提供更大的灵活性并且有助于保证血液供应的安全。”HTLV-I和HTLV-II的都可以通过输血，注射器，受感染的母亲

朵 0.5-4 HZ 的纯音听力频率平均值来界定听力阈值。听力可由此分为：≤ 25 dB 无听力障碍；26-40 dB 轻度听力障碍；>40 dB 中/重度听力障碍。研究发现，中/重度听力障碍者与无听力障碍者相比，其记忆与整体认知功能 20 年下降率有显著差别；而且，未佩戴助听器患者认知功能下降

主办单位：中国人民大学卫生医药发展中心 学分：国家级 I 类学分 6 分 一、培训内容 1、临床路径制定与实施及效果评价；2、临床路径管理的实现策略...中国医院协会评价评估部主任 四、会议费用 会费 1280 元/人 (含国家级 I 类继续医学教育学分 6 分、资料等)，6 人免 1 人培训费，食宿统一安排

3.3 6.4 14.1/7.9ESR 86mm/L肝功能ALT AST PAB ALB GLO TB DB...病毒全套 HSV-I-Ab阳性，余阴性风湿全套ASO、RHF、AAG正常3.3 3.10CRP35.30mg/L

由江苏省肿瘤医院、江苏省抗癌协会肿瘤标志专委会、江苏省生物化学与分子生物学会主办的「第九届肿瘤标志物临床应用与研究进展会议」定于 2018 年 7 月 13～15 日在南京举行。国家级 I 类继续医学教育学分 10 分 [项目编号：2018-11-00-355 (国) ]。本次会议的主题是肿瘤标志物临床应用与研究进展

；(2)适用于包括I临床试验在内的科学研究的研究标准。后者纳入了基于影像技术及脑脊液检查的生物标志物的应用。并根据所出现的牛物标志物的性质。将最终MCI诊断的确

毒副作用，并且周围性神经病的发生率较低。这个I/II实验的目的是明确CMP的最大耐受剂量（MTD），以评价在刚刚确诊的大于65岁的多发性骨髓瘤患者中使用该治疗方案的安全性和有效性。方法：在I期实验，Cfz是唯一剂量变化的药物，最小剂量为20 mg/m2（第一水平），最大预计剂量为36 mg/m2(第三

由广州军区广州总医院主办的“第五期全国经口寰枢椎复位内固定（TARP）技术暨颈椎前后路内固定技术学习班”，定于2014年5月16日-18日在广州军区广州总医院举行。为国家级、全军级和广东省级继续医学教育项目，将授予I类学分证书（8分）。本期学习班将介绍和推广广州军区广州总医院

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

)。共有43%的肢端肥大症患者出现了听力丧失，20%的患者至少有一只耳发生了耳炎。肢端肥大症患者和对照组的纯音平均中位数（PTA）分别为12.5 dB (范围: 2–72 dB)和8.3 dB (范围: 0–20 dB) (P < 0.001)。在患病的三个亚组中PTA没有显著差异

管理，降低院内感染的发生，促进医护间相互交流。根据“2013年I类继续医学教育项目，中国医师协会培训部与医学继续教育网决定在泰安举办...I类继续医学教育证书。五、联系方式手机/短信：15662086720（会议秘书处王老师）