小花是研究生应届毕业生，毕业找工作，顺利进入了一所三甲医院，但是接下来的发展让她有些始料未及。坑 1 ：新科室业务少，陷入政治斗争当初小花面试的时候发现...启示意义。排坑大法 1 ：科室招聘人数多需详细了解用人原因首先，在找工作的时候如果一个科室招聘的人数比较多，一定要仔细分析一下是哪种情况。是科室的业务发展特别

1型糖尿病与免疫学术研讨会定于2010年8月在北京市召开，会议旨在交流和讨论我国在1型糖尿病和免疫领域研究的最新进展。

以上 DKA 须静脉补液，先补给生理盐水，血糖降至 13.9 mmol/L 时根据血钠情况补充 5% 葡萄糖液或葡萄糖盐液（每 2-4 g 葡萄糖加入 1U...1. 仔细询问既往病史及发病前情况1 型或 2 型糖尿病均可发生 DKA，2 型糖尿病的 DKA 多存在诱因，如急性感染、胰岛素不适当减量或突然中断治疗

以上 DKA 须静脉补液，先补给生理盐水，血糖降至 13.9 mmol/L 时根据血钠情况补充 5% 葡萄糖液或葡萄糖盐液（每 2-4 g 葡萄糖加入 1U...1. 仔细询问既往病史及发病前情况1 型或 2 型糖尿病均可发生 DKA，2 型糖尿病的 DKA 多存在诱因，如急性感染、胰岛素不适当减量或突然中断治疗

growth factor (VEGF)A and angiopoietin (Angpt)1 are constitutively expressed... type-1 diabetic mice this milieu of vascular growth factors was altered

21:00 限时 1 元秒杀获得该课程永久观看资格！秒杀规则：19 日（周四）晚 21:00 打开用药助手本文获取优惠码，进入课程购买链接并输入优惠码，即可 1 元

「轻度脂肪肝」不痛不痒，无关紧要？上海全景医学影像诊断中心告诉你 1 个坏消息：轻度脂肪肝会增加 71% 死亡风险。2020 年 10 月...，脂肪肝还会引发多种疾病：1. 诱发动脉硬化，高血压，冠心病等；2. 常合并糖尿病、代谢综合症等疾病；3. 导致肝功能异常，引起消化性疾病、降低免疫力

在斑片状实变，下肺为主」（图 1）。痰培养示豚鼠气单胞菌。给予「亚胺培南、万古霉素、氟康唑」及对症退热化痰治疗。症状未见明显缓解，遂转入上级医院，予「莫西沙星...糖尿病 4 年，口服二甲双胍早 500 mg，晚 1000 mg qd，血糖控制在 5～7 mmol/L。图 1 外院肺部 CT图 2 复查肺部 CT入院查体：体温

1960 年，神经外科成功开展了国内第 1 例帕金森立体定向苍白球损毁术。

根据卫生部门统计数据，我国每年约有100万名器官衰竭患者，其中约有30万人急需器官移植，但仅有约1万人能够获得器官移植手术机会。如何缓解这一巨大的供需矛盾，挽救更多患者的生命，在今年两会上，代表委员们纷纷呼吁完善器官捐献管理体制，树立提倡器官捐献的社会风尚。捐献渠道不明致供需矛盾巨大

神秘世界吧~手机转过来，发福利啦6款礼品，100%中奖活动礼品一等奖1名：坚果手机老罗家的产品，设计...、10积分、20积分可在商城里兑换精美商品若要获得更多积分可去任务中心赚哦抽奖流程简单三步走：1、点击文章底部链接进入抽奖

【摘要】：正目的探讨 PI3Kδ抑制剂 CAL-101 对多发性骨髓瘤 IgE 型细胞系 U266、IgG 型细胞系 RPMI8226 和骨髓瘤患者原代细胞的作用和机制, 为这类疾病的治疗提供新的思路。方法用不同浓度的 CAL-101 处理多发性骨髓瘤细胞系 U266、RPMI8226, 以 MTT 法检测

、吸氧、绝对卧床、去枕侧卧位；垂体后叶素 18u＋NS40 ml ivvp（4 ml/h）;蛇毒凝血酶 1u iv；卡洛环钠针 80 mg ivgtt；止血敏 6...物用法如下：酚磺乙胺针 3000 mg ＋ 氨甲苯酸 500 mg ＋ 5% GS 250 ml ivgtt；凝血酶原复合物 600u ivgtt维生素 K1

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

SEARCH 研究分析显示，Omega-3脂肪酸和亮氨酸可能有助于保护新诊断的1型糖尿病儿童胰岛β细胞功能。较高基线水平的血浆omega-3s...是用来表示2年后平均胰岛素产生水平的指标。来 自北卡罗来那大学的Elizabeth Mayer-Davis博士和她的同事说：“这代表了一个改善1型糖尿病预后

病史简述：患儿，男，11 岁 9 月，因「反复呕吐 1 月余」入院。现病史：患儿于 1 月前无明显诱因下出现上腹部疼痛，不剧伴恶性及反酸，后出现呕吐，发生...包括非特异性高位肠梗阻症状，如餐后上腹疼痛、早饱、上腹胀及呕吐 [1]，全身症状为消瘦、营养不良等改变。因其临床症状非特异性，常导致漏诊、误诊。腹主动脉

据上海卫计委网站消息，上海市卫生和计划生育委员会今日通报，上海市报告1例感染H7N9病毒确诊病例。患者，倪某，男，59岁，本市户籍。于1月1日确诊，现正在积极救治中。

人源平衡型核苷转运蛋白1（hENT1）作为吉西他滨用于晚期胰腺癌治疗效果的预测性生物标志物，其作用目前仍不清楚。罗氏制药公司同德国慕尼黑...单克隆抗-hENT1抗体进行标准化免疫组织化学分析，对hENT1表达进行检测。表1. AIO-PK0104研究中原发性肿瘤及转移性肿瘤样本中

以程序细胞死亡-1（PD-1）/程序细胞死亡配体-1（PD-L1）通路为靶点的免疫治疗已经成为肺癌的标准治疗。PD-L1 的表达可能是免疫治疗的疗效预测标志，但是肺鳞癌中 PD-L1 阳性表达和临床病理学特征及患者结局的相关性还不清楚。日本九州大学的 Kazuki Takada 等人探索了肺鳞癌中 PD-L1 表达