尚未成熟，与大龄儿童相比有其特点，本研究回顾了19例1岁以内婴儿，采用腹腔镜下食管裂孔疝修补联合胃底折叠术治疗的先天性食管裂孔疝患儿，对其疗效和预后进行评估...折叠术的患儿。平均年龄0.52岁（0～30d3例，31d至1岁16例）。男性12例，女性7例。按照美国消化及内镜学会分类Ⅰ型疝（滑疝）12例，Ⅱ型疝（旁疝）5例

N1展馆

famous companies such as Amy Kanghuai Biopharmaceutical (Jiangsu) Co., Ltd.，Jiangsu Jindike Biotechnology Co., Ltd.，ZhongchongXinnuo Biotechnology (Taizhou

也未见记载。最近我们收治1 例多发性骨髓瘤患者，纤维蛋白原高达8.89 g/L，结合文献复习报告如下。1.病历摘要患者，男，57 岁...沉降率（ESR）35 mm/1 h，C 反应蛋白（CRP）37.2 mg/L；肝功能：丙氨酸转氨酶（AST）19 U/L，天冬氨酸转氨酶（ALT）34 U/L

＞25000 IU/ml，HBeAg 907.64 S/CO，HBcAb 8.17 S/CO，肝功能显示 ALT 176U/L、AST 86U/L，肾功能正常，肝纤...谱、腹部彩超等。（相关指标见表 1）。表 1 患者使用 TAF 后 ALT、肌酐、HBV DNA 的变化情况注：*表示急诊生化检验，#表示患者于当地医院复查。三

,HBcAb0.005s/co（罗氏公司，以下同）腹部磁共振提示未见明显异常，肝穿病理提示G1S1。家族史：其妹妹HBsAg阳性。既往史及个人史：无手术、输血史...^7IU/mL,乙肝三系HBsAg900.5IU/ML,HBeAg1872s/co, HBcAb0.008s/co,肝功能正常，再次肝穿病理提示G2S1， 给予

，2015年才开始没多久，作为免疫治疗领域明星选手的PD-1抑制剂的竞争已经开始上演了。PD-1/PD-L1免疫疗法是当前备受瞩目的新一类抗癌免疫疗法，旨在利用人体自身的免疫系统抵御癌症，通过阻断PD-1/PD-L1信号通路使癌细胞死亡，具有治疗多种类型肿瘤的潜力,有望实质性改善患者总生存期。目前，在该领域处于领先地位的

细菌菌株，并添加了 L-半胱氨酸和维生素 B12，以及发酵米糠、糊精、脂肪酸镁盐和磷酸钙等其他物质。在喝酒之前 1-12 小时服用，在喝酒后，这两种细菌会在酒精... 23 日发表在了 Nutrition and Metabolic Insights 期刊上【1】。在这项针对 24 名健康的白人受试者的小型双盲对照临床试验中

重症监护室）持续观察。小异物引发大抢救尽管实施了气管插管，在呼吸机的辅助通气下，小西仍呼吸急促、口周紫绀，出现了 CO2 潴留，严重的酸中毒，必须立刻救治。儿科二...放在儿童拿不到的地方，年幼儿童需在监护下玩耍。急救措施NO.1 徒手急救适用于误吸异物出现呼吸困难、窒息时。1. 上腹部拍挤法（海姆立克式法）：适用于

第五主会场（Simultaneous Main Session, No.5）癌痛规范化处理专题研讨会（GPM Symposium）团体会员协办（Coadjutant）：北京萌蒂制药有限公司地点（Place）:上海光大会展中心1楼光韵1号厅执行主席（Co-Chairs）：徐建国教授 于世英

，所以 PCO2 的变化与 H2CO3 变化一致。01、参考范围（1）pH 值：7.35 ～ 7.45都说今天是被血气气死的一天了，所以 pH 值就在气伤...。H2CO3 和 HCO3- 不似普通情侣那般 1 v 1。20 v 1 才是恰到好处。这个比例正好能让人类幼崽 ——pH 值维持在正常「气人」水平（气伤

会议现场1

统计，目前全球约有 2.96 亿乙肝携带者，我国每年的新发乙肝病例仍达到百万[1]。慢性乙肝感染至今无法治愈，其根源在于乙肝病毒基因组里共价闭合环状 DNA...，以及超低温冰箱、发酵罐、生物反应器、CO2培养箱、生物摇床等等，耗材类包括如移液吸头、离心管、PCR 板、微孔板和一次性生物反应器罐体等高性能的优质产品

Section 1 开幕式现场精彩图片可进入「会场掠影」观看：http://meeting.dxy.cn/specials/2015invasive/tag/venue

据路透社报道，Teva 制药工业公司 2 月 1 日表示表示，欧洲药品管理局（EMA）专家小组已建议批准旗下偏头痛治疗药物 Ajovy。该药物被视为令梯瓦业绩...公司之一 Express Scripts Holding Co 表示它已将 Eli Lilly 和 Amgen Inc 的新偏头痛药物纳入报销范围，但并未包括梯瓦

先天性耳畸形手术治疗镫骨手术及计算机辅助CO2激光在耳科中的应用人工耳蜗植入术振动声桥适应症选择及手术方式骨锚...;学时： 40学时学分授予：完成学习班全部课程，授予国家级I类学分10分，请提供1寸照片1张，另交20元工本费

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

通知，会期预计3天）甘肃省敦煌市四、征稿范围1．高压氧治疗的临床经验总结、方法创新和机制研究；2．其他气体（氢、氦、氙、CO...、潜水监督等）。五、征文要求1、文字简洁，数据准确，重点突出，观点鲜明。2、论文全文不超过5000字，论著请附300字左右的中文

实验课堂1 摘要