筛查疾病筛查方案唐氏综合征（21-三体综合征）孕早期两联：PAPP-A，free β-hCG爱德华氏综合征（18-三体综合征）孕早期两联联合颈部半透明带厚度：PAPP-A，free...

Comparative and evolution genomics-112003 2004 广州SARS的流行病学...广东SARS病人的流行病学分析和SARS流行病学分期-6还应该做什么研究？-18基因组进化的分子标记

提供了技术保障。Label-free shotgun：无标签标记的定量蛋白质组学研究，依赖于繁杂的信息分析完成定量过程，主要有两种：信号强度和谱图计数法[1

Background. Hepatitis C virus (HCV) is spread through direct contact with blood, although alternative routes of transmission may contribute to the global burden. Perinatal infection occurs in up to 5% of HCV-infected mothers, and presence of HCV RNA in breast milk has been reported. We investigated the influence of breast milk on HCV infectiousness.Methods/Results. Human breast milk reduced HCV infectivity in a dose-dependent manner. This effect was species-specific because milk from various animals did not inhibit HCV infection. Treatment of HCV with human breast milk did not compromise integrity of viral RNA or capsids but destroyed the lipid envelope. Fractionation of breast milk revealed that the antiviral activity is present in the cream fraction containing the fat. Proteolytic digestion of milk proteins had no influence on its antiviral activity, whereas prolonged storage at 4°C increased antiviral activity. Notably, pretreatment with a lipase inhibitor ablated the antiviral activity and specific free fatty acids of breast milk were antiviral.Conclusions. The antiviral activity of breast milk is linked to endogenous lipase-dependent generation of free fatty acids, which destroy the viral lipid envelope. Therefore, nursing by HCV-positive mothers is unlikely to play a major role in vertical transmission.

为神经干细胞的获得提供了一种新的高效的方法。

论文识别出了人类和犬乳腺肿瘤的重要相似之处和差别，为使用犬模型系统的未来研究提供了一个强有力的平台。\r\n\r\n

联合化疗效果更好 -5EBCTCG Meta-Analysis (2005-06)-6Evolution...最大累积剂量-17阿霉素累积剂量与心衰发生的关系-18蒽环类药物心脏毒性-19蒽环类药物

乳腺癌BOLERO-2研究最终结果：近年来乳腺癌治疗中关于依维莫司的研究数据令人鼓舞，基于BOLERO-2临床研究结果于FDA获批。近期BOLERO-2研究的最终结果发表，确认了对ER+，HER2-的晚期乳腺癌患者，在内分泌治疗进展后进行内分泌和mTOR通路的双重封锁能够带来PFS获益。

microRNA-34a tp53在白血病发病的作用

Evolution of Guidelines for ACS-36GRACE risk score-30...时代-35长期用药-46初始心电图的特征和AMI-17初始心电图与AMI的可能性-18

简介The Leipzig University (German: Universit?t Leipzig), located in Leipzig in the Free State of Saxony, Germany, is one of the oldest

丁香诊所是一家基于互联网实践的线下医疗诊所，为了增强诊所医生护士对全科医学知识和技能的掌握，为病人建立一个 worry-free（完全信赖）的就医环境，丁香...Palliative and hospice care 老年痴呆Dementia and Alzheimer9-18 星期五 (Fri

are known to play central roles across numerous biological processes required for cell

Family physicians play a crucial role in the management and ongoing care of patients with Alzheimerdisease (AD). This article reviews the effects

2012年9月期的Trends in Ecology & Evolution发表了一篇挺有意思的文章，题目是“学术界沉迷于数量...研究组不要过大吗？你在合理使用经费吗？你兼顾了工作和生活的平衡吗？Cited from Fischer J. et al. (2012

Dendrites play a central role in neuronal information processing by integrating thousands of synaptic inputs to generate a meaningful action potential

the genetic bases of evolution, and also promotes the industrialization of biotechnology.... to further understand the genetic bases of evolution and economically/medicinally