“起初，我们只是很惊讶的发现精神分裂症患者声音的基础频率要比正常人高。”图尔大学医院的Dr. Jerome Graux说道：“后来帕金森疾病的相关文献让我们...包括：运动迟缓、震颤以及肌肉强直，而肌肉强直可导致声音基础频率的增高。Dr. Graux及其同事调查了26名服用抗精神病药物的男性精神分裂症患者声音的基础频率

;Dr.E.J.Corey(Nobellaureate,&nbsp...;University)Dr.WilliamGreenlee(FormerVP 

，如下：Dear Dr.,Thank you for your submission.I have looked it through... you very much.过了2周不到，文章修回：Dear Dr.,I am pleased to inform you

临床指标相关菌群的重要一步，表明肠道微生物区可能在有一天成为药物处理、饮食或生活方式改变的标靶。”Dr. Fraser说：“有必要进行更深入的研究，包括对阿米什人进行介入性研究。我们可以着眼于这些细菌是否会在特定的个人随着时间的推移或饮食、药物处理等改变。“Dr

策略的奠基石，”研究的首席作者Dr. Nitika Pant Pai说，他是RI-MUHC的医学科学家和麦吉尔大学的医学副教授，“虽然以前的研究显示HIV感染的唾液检测OraQuick HIV1/2有很高的准确性，但我们的研究是第一个对它进行全球水平的评价”Dr

Upstate Medical University的Dr. R. B. Barlow和他的同事在当前的实验中测试了一种缺乏胰高血糖素受体而致低血糖小鼠的视网膜功能...和归因于代谢性应激如黄斑变性而致视网膜疾病的重要性，” Dr. Barlow的小组得出这个结论。 Hypoglycemia Promotes

and Immunotoxicity Conference to be held on January 29-31, 2014 in San Diego, CA . Dr

of our meeting, Dr. Valerie Horsley from Yale University will precept a Scientific

, 葛兰素史克,诺华, 默克, 强生, 雅培,拜耳，罗氏, 诺和诺德, 武田, 印度 Dr. Reddy's, Ranbaxy, 上海医药集团, 中国医药

email至本次学习班专用信箱：dr.liubo@gmail.com2．拨打报名电话： 13659867877 刘波博士

;Dr Mahesh Jayaram –英国国家国民保健信托基金会精神科主任医师；Cochrane精神分裂症专业组编辑（Editor

分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer

中国医生们在学术出版方面的宝贵建议。嘉宾简介采访视频ccvideo为什么选择加入 JAMA/ICVTS？Dr. Grouse：我在 NIH（美国国立卫生研究院... 拥有更多机会，并且有强大的读者群，能够代表美国的整个医学界发声。所以我就加入了 JAMA，并在那里做了五年的全职编辑。Dr. Sihoe：我加入 ICVTS

、Force 双源 CT、双板 DR、乳腺 DR、4D 彩超等全套西门子医学影像设备，是亚太地区颇具规模的专业医学影像诊断机构。

前沿医学影像诊断设备，包括西门子 PET/MR、PET/CT、3.0T MR（全静音）、Force 双源 CT、通用型 DR、乳腺 DR、4D 彩超、ABVS

口腔科主任，口腔种植修复学博士，副主任医师。美国常春藤名校宾夕法尼亚大学牙学院访问学者，师从著名的牙周种植专家 Dr. Graves 和 Dr. Lee 教授。专业特长：口腔种植术及上部修复，咬合重建，固定义齿美容修复（烤瓷冠、全瓷冠、贴面、嵌体、桩核冠等）、活动义齿及全口义齿修复。曾多次参加国内外口腔种植修复

society for the study of breast milk and lactation (ISRHML). Dr. Lönnerdal’s... collaborative projects in China, Peru and Sweden. Dr. Lönnerdal has published more than

）Dr.Lucci 结合临床真实案例，从如何避免过度治疗、治疗方案的选择、放疗、乳腺癌精准医疗的发展等方面，详细讲解介绍了 MD 安德森癌症中心关于乳腺癌的最新治疗方式。会议采取即时提问、讲解和讨论同时进行的方式，氛围轻松而又不乏严谨。Dr.Lucci 一边讲解一边回答各位专家提出的问题，中美专家就一些

、CT 提示胆总管扩张，动态 DR 钡餐检查获得以下高清晰的点片影像：图 1：下箭头示十二指肠降段内侧小憩室，憩室颈部狭窄，内见气液平面。图 2：右箭头示憩室周围肠黏膜皱襞增粗，排空延长，提示憩室炎。动态 DR 在十二指肠憩室检查中的应用动态 DR 矩形采集面积大，一次曝光即可显示胃及十二指肠，同时在可视化操作及多角度

Karmanos 癌症研究所的 Dr. Gadgeel 指出，辅助化疗可以作为 IB 期肿瘤 ≥ 4 cm、II 期或 IIIA 期 NSCLC 的标准治疗，5 年生...以铂类为基础的化疗，根据切除组织的病理学选择配伍化疗药。Dr. Gadgeel 认为化疗时机很重要，术后化疗越早越好，但如患者较虚弱，需恢复体力，在术后 4