据英国哥伦比亚大学研究人员称，重度流感有倍增晚年患帕金森综合症的风险。然而，对于在小时候感染过典型红疹的人来说，结果恰恰相反，他们患帕金森综合症的可能性要低35%。帕金森综合症是一种神经系统混乱性疾病，疾病特征是移动缓慢、摇摆不定、动作僵硬，并在后期失去平衡。英国哥伦比亚大学人口和公共卫生学院及太平洋帕金森症研究中心的研究人员的该研究发现，在线发表在这个月的《运动障碍杂志》。该发现是基于对英国哥伦比亚和加拿大40 ...

和 RCODOX-M/R-IVAC 也是备选方案（2C）。3. 根据英国血液学标准委员会（BCSH）指南，进展期 DLBCL 患者均应进行 CNS 的预防治疗（2B）。4....）。6. 免疫化疗结束后，建议对原发部位的瘤体（直径 >7.5 cm）或结外累及部位进行放疗（1B）。7. 除临床试验之外，判断 DLBCL 起源于

＞25 kg/m2 的 T1DM 患者被随机分为利拉鲁肽 1.8 mg 组及安慰剂组，2 组均接受同样胰岛素治疗。1. 12 周后，与安慰剂组比，利拉鲁肽降低...体重增加和低血糖是 T1DM 患者使用胰岛素治疗的常见副作用。胰岛素联合 GLP-1 受体激动剂对于 T2DM 患者可有效减轻体重增加、减少胰岛素剂量

Shah, S. P., Kobel, M., Senz, J. et al.案例简介...成年GCTs中FOXL2有一个402位C至G的突变。♦ 案例二Nature Medicine, 2010, 16(7

。为验证这一假说，来自美国梅奥诊所肺病和危重医学科的Susan M. O'Gorman及其同事进行了一项研究，研究结果在线发表于2013年1月3日的...，43人被随机给予标准治疗，另43人被给予标准治疗加术后APAP。在2个随机分组患者之间，研究者没有发现其住院时间（P = 0.65）或任何次要终点事件有显著性

0.05cm2面积信号与C7-T1椎间盘平面脊髓内0.3cm2信号强度的比值，图1，图2）。对T1和T2相信号强度比与术前JOA评分，JOA恢复率，病程长短和MRI形态...颈椎病病例，随访提示66.7%的神经功能改善（JOA评分14到16）。(A)矢状面正中T1相MRI，(B)矢状面正中T2相MRI。注意C4-5水平髓内高信号。(C

来自中国人民解放军总医院的母义明教授将在第 75 届 ADA 年会上作报告：利格列汀（L）二甲双胍（M）固定剂量复合剂 (FDC) 作为伴严重高血糖的亚洲 2...量复合剂对 HbA1c ≥ 11% 的 2 型糖尿病患者初始治疗的效果。患者被随机分配至利格列汀 2.5 mg/二甲双胍 1000 mg BID（L2.5/M，72

、免疫表型分析和功能方法，鉴定出大量共表达 TCF7 和 LEF1 的 2 型辅助 T (TH 2) 细胞，以及慢性激活的特征。将 TH2-MPP 确定为异常 T... |T cell help induces Myc transcriptional bursts in germinal center B cells

准确预测T1D风险的ABRS中。研究结果在线发表于2013年7月1日美国的《糖尿病治疗》(Diabetes Care)杂志上。研究对象为784名...，ABRS可有效预测T1D风险(危险比[95% CI] 2.72[2.23-3.31]，P<0.001)。ABRS接受者操作特征(ROC)曲线下面积(95

)上，美国内布拉斯加大学医学中心的Julie M. Vose等人发表了BMTCTN0401临床试验的III期结果。该项临床试验面向弥漫性大 B 细胞淋巴瘤(DLBCL...(第-5天至第-2天)、每日两次每次100 mg/m2的阿糖胞苷(第-5天至第-2天)、140 mg/m2美法仑(第-1天; B-BEAM)治疗，或在第-19天

美国布莱根妇女医院血液科的 Maureen M. Achebe 等教授就妊娠期贫血的诊断、治疗以及发病原因进行了讨论与总结，文章发表在近期出版的 Blood...口服铁剂 3～6 个月或至产后 3 个月」。叶酸和维生素 B12 缺乏性贫血叶酸和维生素 B12 参与四氢叶酸代谢，是 DNA 合成的必需元素。营养不良、肠道

健身器材；参展费用◆T区(光地)：800元/m...2)◆B区(标准)展位：人民币7500元/个(3×3m2)◆C区(非标)展位：人民币3800元

&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了&ldquo;常见重大疾病全基因组关联分析和药物基因组学研究&rdquo;的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
&nbsp;BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives&bull; To better understand the potential applications of GWAS
&bull; To address practical issues in study design, implementation, and data analysis of GWAS
&bull; To promote interaction and collaboration among researchers who are interested in GWAS
&bull; To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
&bull; To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
&bull; Breast cancer in Chinese populations Xiao-ou Shu
&bull; Genetic association studies of skin cancer Jiali Han
&bull; Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
&bull; Genetic association studies of lung cancer in Chinese populations Daru Lu
&bull; Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
&bull; Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
&bull; Genetic association studies of hypertension in Chinese populations Jiang He
&bull; GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
&bull; Molecular epidemiology of diabetes in Chinese populations Weiping Jia
&bull; Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
&bull; Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
&bull; Genetic structure of Chinese population Li Jin
&bull; High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
&bull; Molecular genetics study of neural tube defect Hongyan Wang
&bull; Risk prediction using genetic variants in prostate cancer Jianfeng Xu
&bull; Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
&bull; Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)&bull; Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
&bull; Genetic epidemiology of skin cancer and breast cancer
&bull; Genome-wide association studies
&bull; Gene-environment interaction&bull; Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
&bull; Genetic epidemiology of hypertension
&bull; Gene-nutrition interaction of cardiovascular disease&bull; Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
&bull; Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
&bull; Genome-wide association studies
&bull; Genetic variants and association study&bull; Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People&rsquo;s Hospital, Shanghai Jiaotong University, Her major research area is:
&bull; Molecular endocrinology and diabetes&bull; Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
&bull; Genetic and molecular epidemiology of lung cancer and glioma
&bull; Genetics of metabolism diseases
&bull; Genetic markers for population genetics&bull; Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
&bull; Genetic and molecular epidemiology of lung cancer and glioma
&bull; Genetics of metabolic disease&bull; Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
&bull; Genetic and lifestyle predictors of cancer and other chronic diseases
&bull; Cohort study methodology
&bull; Incorporating biomarkers in risk prediction&bull; Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
&bull; Translational cancer research
&bull; Gene expression profiling
&bull; Cancer genome high-throughput sequencing&bull; Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
&bull; Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)&bull; Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
&bull; Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
&bull; Genetic susceptibility to cancer
&bull; DNA repair and apoptosis phenotype markers&bull; Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
&bull; Genetic epidemiology of prostate cancer
&bull; Genome-wide association and fine mapping analysis
&bull; Risk prediction using genetic markers and other clinicopathologic variables&bull; Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
&bull; Molecular epidemiology of smoking-related cancers
&bull; Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
&bull; Gene-environmental interaction between genetic markers and environmental factors&bull; S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
&bull; High-throughput genotyping and sequencing
&bull; Genetic epidemiology of prostate cancer&bull; Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
&bull; molecular and genetics of complex diseases&bull; Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
&bull; Molecular and genetics of cardiovascular diseases&bull; Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
&bull; Topic of presentation: Molecular epidemiology of stomach cancer
&nbsp;

粒细胞缺乏、输血依赖性贫血、血小板减少、严重的 B 症状、迅速增加的循环淋巴细胞[7,9]。由于缺乏大的前瞻性队列研究，目前暂无 T-LGLL 一线治疗的指南...αβ+同时伴有 T 系抗原 CD2、CD5、CD7 的表达减弱或者缺失[2,3]，少见表型有 CD3+CD4+CD8-CD57+CD56-TCR

training seminars.John obtained B.S. and M.S. degrees (with honors...Michael B. BolgerChief Scientist

training seminars.John obtained B.S. and M.S. degrees (with honors...Michael B. BolgerChief Scientist

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