完全缓解率为33%。帕克在AACR年会报告上称，专门为此项试验设计的统计模型表明：此方案在Ⅲ期临床试验中有95%的可能性优于标准疗法，并且有79%的可...（赫赛汀）+紫彬醇来说，通过率可达到79%。来那替尼在HER2+/HR－标签中也优于曲妥单抗能达到95%的通过率。腹泻的毒副作用并不明显，且易于控制。另外

展示和分享陆道培医学团队最新科研成果。研究一：使用 cCD79a 设门的多色流式可以有效监测 CD19-CAR-T 治疗 B-ALL 后 MRD，并且预测桥接移植的预后第一作者流式细胞室陈曼医师的文章「Multicolor Flow Cytometry Panel with cCD79A Gating

各有关单位：

当前，我国政府从监管和科技层面都对临床前药物安全性评价研究给予了高度的重视和支持，在国家高技术发展计划(“863” 计划)和“国家重大新药创制”科技重大专项中，都将临床前药物安全性评价研究列为重要内容；而重视药物安全性评价是新药研发的国际大趋势，提高药物安全水平也是保障人民健康的必然要求。为适应我国创新药物研究与开发的需要，紧密结合我国新药临床前安全评价的GLP要求，进一步增强创新性药物非临床研究中安全性、有效性的研发思路、评价与实践的交流，以应对我国药物安全性评价研究特别是临床前药物毒理学研究面临机遇和挑战。经研究，全国医药技术市场协会于2012年9月3日-6日在上海市举办“药物非临床安全评价关键技术研讨会”。请各有关单位积极派员参加，现将有关事项通知如下：

一、会议时间地点：

时间：2012年9月3日-6日（3日全天报到）

地点：上海市（地点确定直接通知报名者）

二、会议主要交流研讨内容：

1.国内外GLP的现状及展望

2.药物GLP认证检查标准、程序及要求

3.新药早期毒性评价优化筛选系统的建立与应用

4.毒理基因组学技术在新药研发中的应用

5.创新药物安全性研究新思路、新技术与新方法介绍

6.生物技术药物安全性评价关键技术介绍

7.新药非临床安全性评价研究的实验设计、实施与综合评估

8. 药物毒理学研究新思路、新技术与毒性评价新方法

9.药物上市后再评价

10.不同注册分类新药的安全性评价要求及常见问题

11.新药临床前药效学研究技术要求及非临床药效学试验设计

12.新药潜在的肝肾毒性评价

三、参会对象：

药物研究机构及制药企业中从事临床前安全性评价相关工作的人员；药物安全评价机构毒理学试验研究人员；药物非临床试验毒性病理试验研究人员；药品研发机构和制药企业药物研发与产品注册人员；CRO公司从事药物非临床安全性评价相关人员；进出口检验机构的试验研究人员以及其他与非临床安全性评价相关的工作人员等。

四、会议费用：

会务费：1980元/人；费用含专家费、会务费、资料费等；食宿统一安排，费用自理。

五、会议形式说明：

1. 邀请知名专家理论讲解,实例分析,专题讲授,互动答疑。

2. 可采用现场演讲、实物展示、图片展览、多媒体展播、会刊等多种方式对推介相关技术（产品）进行介绍。

3、本次研讨会将面向全国征集与主题相关的学术报告、论文、调研成果，将择优选用并安排会议发言。

4、论文来稿应具有科学性、实用性，且论点鲜明、数据可靠、文字精练通顺，文稿请用word文档（A4纸）电子邮件投递至专用信箱，一般文章以3000～5000字为宜。来稿须列出题目、作者姓名、工作单位、地名（城市）及邮政编码、论文摘要、关键词、正文、主要参考文献。多位作者的署名之间，应用空格隔开。不同工作单位的作者，应在姓名之后标注作者工作单位，并列出工作单位、地名、邮政编码。截稿日期：2012年8月24日。

六、联系方式：

电话：010-51795206 13811915260

传真：010-80115555 转775080

报名邮箱：pharm@263.net 联系人：王旭东

二零一二年七月

附件一：

日程安排表

9月4日 （星期二） 09:00-12:00	一．药物研发中的非临床安全性研究 二．全程式安全性评价在药物研发中的应用（包括上市后在评价等） 三．新药早期毒性评价优化筛选系统的建立与应用 主讲人：廖明阳 军事医学科学院
9月4日 （星期二） 14:00-17:00	一．国内外GLP的现状及展望 二．药物GLP认证检查标准、程序及要求 主讲人：国家食品药品监督管理局药品认证管理中心相关专家
9月5日 （星期三） 09:00-12:00	一．药物毒理学研究新思路、新技术与毒性评价新方法 二．新药潜在的肝肾毒性评价（药物肝肾毒性检测体系的建立与应用） 主讲人：中国科学院上海药物研究所相关专家
9月5日 （星期三） 14:00-17:00	不同注册分类新药的安全性评价要求及常见问题 主讲人：（国家）上海新药安全评价研究中心相关专家
9月6日 （星期四） 09:00-12:00	生物技术药物临床前安全性评价研究进展与应用 主讲人：中国食品药品检定研究院安全评价研究中心相关专家
9月6日 （星期四） 14:00-17:00	一．创新药物安评研究设计、总结评估关注点探讨 二．新药临床前药效学研究技术要求及试验设计 三．新药非临床安全性研究的实验设计和实施 （包括试验设计、动物选择、具体实施及指导意义） 主讲人：袁伯俊 第二军医大学药物安全性评价中心
备注	每天除专家报告外，还安排了约1小时的代表发言和提问时间

附件二：

药物非临床安全评价关键技术研讨会回执表

单位名称
通讯地址							邮编
联系人				电 话			传真
参 会 人 员 名 单
姓 名	性别		部门	职务/职称		手机	电子邮件
住宿预订			□双人标准间 □单人间 拟住日期：2012 年 月 日— 月 日
是否提交论文：					其它要求：
企业展示		□发言 □发资料 □展位 □会刊彩页 □易拉宝 □其它
电话：010-51795206 13811915260 报名邮箱：pharm@263.net传真：010-80115555 转775080 联系人：王旭东

参会名额有限，请尽快传真至010-80115555转775080或发邮件至pharm@263.net

The 9th International Bioinformatics Workshop (IBW2011)
July 11-13, 2011. Xi’an, China
Announcement for Papers
（Submission deadline: April 15, 2011）

Sponsored by:
Committee of Tumor Marker, Chinese Anti-Cancer Association
Medical & Health Engineering Division of the Chinese Academy of Engineering
Organized by:
The Cell Engineering Research Center, Fourth Military Medical University
The School of Biomedical Engineering, Fourth Military Medical University
Co-organized by:
Medical & Health Engineering Division of the Chinese Academy of Engineering
Sponsored by:
National Science Foundation of China
FourthMilitary Medical University
Ministry of Education, China.
Workshop Website:
http://ibw2011.fmmu.edu.cn
Welcome Message
The International Bioinformatics workshop (IBW) series aims to promote scientific communication for Chinese researchers on the cutting-edge progress in bioinformatics, computational and systems biology, genomics, and proteomics. As a major annual event in the Chinese bioinformatics community, the workshop series have attracted over 2,000 students and postdoctoral fellows in 8 previous successful meetings, which took place at Fudan University (2003), Tsinghua University (2004), Jilin University (2005), Central South University (2006), Shandong University (2007) and Yunnan University (2008), Soochow University (2009), and Wuhan University (2010), respectively.
IBW2011, organized by the Cell Engineering Research Center and the School of Biomedical Engineering, Fourth Military Medical University, co-organized by the Chinese Academy of Engineering, will be held from July 11th to 13th, 2011, in Xi'an, China. The workshop is sponsored by NSFC, FMMU, and by the Ministry of Education, China. About 20 speakers from both domestic and overseas have agreed to present at the workshop.
Xi’anis one of the most attractive historical cities. Strolling in street of city, one will get the feeling of walking through a big historical museum, in which one can witness the Eighth Wonder in the world- “terra-cotta warriors and horses” of Qin dynasty, the Big and Small Wild Goose Pagodas of Tang dynasty and the city wall of Ming dynasty. We believe that our kind receptions will make this trip a colorful and unforgettable one for you.
Looking forward to meeting you in Xi’an on July 11th -13th, 2011.
Yours faithfully,
Chairman: Zhinan Chen, Ph.D.
Ying Xu, Ph.D

Conference organization

Honorary Chair：	Prof. Daiming Fan	President, Fourth Military Medical University Academician, the Chinese Academy of Engineering (CAE)
Chair:	Prof. Zhinan Chen	Academician, the Chinese Academy of Engineering (CAE) The Fourth Military Medical University, China
	Prof. Ying Xu	GeorgiaUniversity, IBW steering committee member

Program committee:

Chair:	Qian Wang	FourthMilitary Medical University
Co-chair:	Yingming Feng	FourthMilitary Medical University
Secretary:	Jinliang Xing	FourthMilitary Medical University
Member:	Luonan Chen	Shanghai Institute of Biological Sciences, CAS
	Runsheng Chen	Instituteof Biophysics, CAS
	Yuan Gao	Virginia Commonwealth University, USA
	Jingdong Han	CAS-MPG Partner institute for Computational Biology
	Bailin Hao	FudanUniversityand Institute of Theoretical Physics, CAS
	Tao Jiang	Universityof California at Riverside, USA
	Hoong-Chien Lee	National Center University, Taiwan
	Ming Li	University of Waterloo, Canada
	Juan Liu	WuhanUniversity
	Youyong Lv	Beijing University/School of Medicine
	Zhengsu She	BeijingUniversity
	Yu Shyr	Vanderbilt University, USA
	Zhirong Sun	TsinghuaUniversity
	Haixu Tang	Indiana University, USA
	Wen Wang	Kunming Institute of Zoology, CAS
	Stephen Wong	Methodist Hospital Research Institute, USA
	Weixiong Zhang	Washington University, USA
	Xuegong Zhang	TsinghuaUniversity

Steering Committee:

Chair:	Ying Xu	Universityof Georgia
Co-chair:	Liping Wei	BeijingUniversity
	Yixue Li	Shanghai Center for Bioinformatics Technology
	Xiaole Shirley Liu	HarvardUniversity

Organizing committee:

Chair:	Wenbin Li	FourthMilitary Medical University
Co-chair:	Yong Ji	FourthMilitary Medical University
Secretary:	Hongbing Lu	FourthMilitary Medical University
Member:	Dongguang Wang	FourthMilitary Medical University
	Ruian Wang	FourthMilitary Medical University
	Huijie Bian	FourthMilitary Medical University
	Jianli Jiang	FourthMilitary Medical University
	Chun Jiao	FourthMilitary Medical University

1. Workshop Scope:

The workshop will cover the top subjects on computational genomics, computational proteomics, computational systems biology and biological data mining. Submissions of summaries describing original work in, but not limited to, the following topics are encouraged.
1. Computational genomics
2. Bio-sequence analysis
3. Comparative genome analysis
4. Biological networks
5. Computational proteomics
6. Computational structural biology
7. Computational systems biology
8. Biological data mining
9. Computational evolutionary biology
10. Algorithmic and combinatorial methods in bioinformatics.
11. Disease genomics and proteomics

II. Call for summaries and speakers
We are now open to accept contributed talks for all areas in bioinformatics including but not limited to the conference topics. Please e-mail us your intention and a summary of paper to be spoken at the conference and submit your self-introduction for review and evaluation. All submissions will be peer-reviewed by experts in the field independently based on originality, significance, quality and clarity. Authors should format their papers (less than 4-pages) and submit requested files to the workshop mailboxapctbm2009@163.com. Mailing papers are not welcome.
Important deadlines:
Paper submission deadline: May 15, 2011
Notification of paper acceptance deadline: May 30, 2011

III. Rules for Papers (All papers should be organized as following rules):
(1). All Papers (abstract or full text) must be submitted as an unpublished presentation. They must be written in English with Word format to fit into the A4 layout.
(2). Styles of English text are as the followings:
﹡Text format: Times New Roman of 11 pt, single spaced.
﹡Title: Simple and clear, all in capital letter and not bold.
﹡Author has no title name, the first letter capitalized, aligned on the left ( the first name before surname, example: Li Xiangyang is Xiangyang Li ).
﹡Organization, city and country are aligned on the left.
﹡Paper is composed of the followings: Objectives, methods, results, conclusions.
﹡Please be sure to carefully check your paper for content errors, spelling, names, etc, before submitting. We are not able to proofread for or correct spelling, typographical, grammatical, or scientific errors.





IV. Conference Program

DragonStar Course	July 4th	Registration & Picking up course handouts
	July 5th	Morning	Opening Ceremony
			Course Session
		Afternoon	Course Session
	July 6th-10th	All day	Course Session with Projects
IBW2011 Workshop	July 10	All day	Registration
	July 11th	Morning	Opening Ceremony
		Afternoon	Plenary Session
		Evening	Welcome Banquet
	July 12th	All day	Plenary Session
	July 13th	Morning	Plenary Session and Closing Ceremony

V. Invited Speakers:
1、Luonan Chen, Shanghai Institute of Biological Sciences
（陈洛南教授，中科院上海生命科学研究所）
2、Runsheng Chen, Institute of Biophysics, CAS
（陈润生院士，中科院生物物理研究所, 中国科学院院士）
3、Yuan Gao, Virginia Commonwealth University, USA
（高原教授，弗吉尼亚州立邦联大学，美国）
4、Jingdong Han, CAS-MPG Partner institute for Computational Biology
（韩敬东研究员, 中科院遗传与发育生物学研究所）
5、Bailin Hao, Fudan University and Institute of Theoretical Physics, CAS
（郝柏林院士,中科院理论物理研究所，中国科学院院士）
6、Tao Jiang, University of California at Riverside，USA
（姜涛教授，美国加州大学河滨分校）
7、Hoong-Chien Lee, National Center University, Taiwan
（李弘謙教授，国立中央大学，台湾）
8、Ming Li, University of Waterloo, Canada
（李明教授，加拿大滑铁卢大学）
9、Yixue Li, Shanghai Bioinformatics Center，CAS
（李亦学研究员，中国科学院上海生命科学研究院生物信息中心）
10、Xiaole Liu, Harvard University and Tongji University
（Xiaole Liu教授，哈佛大学，同济大学）
11、Youyong Lv, Peking University School of Medicine
（吕有勇教授，北京大学临床肿瘤学院）
12、Zhensu She, Peking University
（佘振苏教授，北京大学）
13、Yu Shyr, Vanderbilt University, USA
（石瑜教授，范德堡大学，美国）
14、Zhirong Sun, Tsinghua University
（孙之荣教授, 清华大学生物科学与技术系 ）
15、Haixu Tang, Indiana University, USA
（唐海旭教授，印第安纳大学，美国）
16、Wen Wang, Kunming Institute of Zoology, CAS
（王文研究员，中科院昆明动物研究所，973首席科学家 ）
17、Liping Wei, Peking University
（魏丽萍教授，北京大学生命科学院 ）
18、Stephen Wong, Methodist Hospital Research Institute, USA
19、Jinliang Xing, The Four Military Medical University
（邢金良教授，第四军医大学细胞工程研究中心）
20、Ying Xu, University of Georgia and Jilin University
（徐鹰教授，乔治亚大学，吉林大学长江学者特聘教授）
21、Weixiong Zhang, Washington University
（Weixiong Zhang教授, 华盛顿大学）
22、Xuegong Zhang, Tsinghua University
（张学工教授, 清华大学生物信息学主任 ）

VI. Registration
Registration for the workshop is free and open to the public. To register for the workshop, please complete the registration form available online at website:http://ibw2011.fmmu.edu.cn, and send the registration form to mailbox ibw2011@fmmu.edu.cn. All registrations will be confirmed by email.
Important dates:
Registration deadline for DragonStar course: May 15, 2011
Registration deadline for the workshop: June 10, 2011

VII. Conference Accommodation Information:
To facilitate the accommodation and make the participation more convenient, we provide the following optional services including lodging and meals that will be charged. Please identify which service you need when you fill the registration form. The reimbursable receipt could be issued for all related payments.
Hotel service: Regular participants need to pay for the hotel fee. The reservation fee of 200RMB is required for each reservation. The conference has arranged two hotels below to choose:A.Xi’an Jianguo Hotel （★★★★）Location: No.2, Huzhu Street, Xi’an City, Shaanxi Province, China
Website: http://www.hotelxianjianguo.com
Tel：86-29-82598888;
Conference room rate：

Jianguo Hotel （★★★★）	Standard Room	Deluxe Room	Executive Suite
	Single/double	Single/double
	￥430/night	￥530/night	US$ 180/night

All room rates include 15% service charge.
B. The Fourth Military Medical University Hotel
Location: No.169, Changlexi Street, Xi’an City, Shaanxi 710032, China
Tel：86-29-84775888
Conference room rate：

The Fourth Military Medical University Hotel	Standard Room	Deluxe Room
	Single/double	single/double
	￥170/night	￥380/night

2. Conference Documents (optional):
150 RMB per copy for 5-day DragonStar course;
200 RMB per copy for 3-day workshop.
Each copy contains the teaching materials required by the course, materials of all invited and contributed talks, the abstracts of all potential accepted papers, a conference programme, a workshop badge, and so on.
3. Meal Tickets (optional):
450 RMB per set for DragonStar course (consists of tickets for five-day meals from Jul.6-10)
600 RMB per set (consists of tickets for four buffet meals and one banquet from July 11 to 13).
Please note that the meal set is nonseparable.

VII. Conference Language: English/Chinese

IX. Contact information:
Questions or comments on the conference:
Contact Person: Professor Lu
Tel: 86-29-84774837, 13572116125
Email:luhb@fmmu.edu.cn
IBW2011@fmmu.edu.cn

Questions or comments on paper submission:
Contact Person:Miss Cheng
Tel: 86-29-84772286
Email:apctbm2009@163.com

Questions or comments on registration:
Contact Person: Teacher Wang
Tel: 029-84774840-802,
Email:IBW2011@fmmu.edu.cn
Fax: 86-29-84774837

Address: The Cell Engineering Research Center/School of Biomedical Engineering
FourthMilitary Medical University,
169 Changlexi Rd, Xi’an, Shaanxi 710032, China.
Website: http://ibw2011.fmmu.edu.cn