will represent a period of rapid growth in understanding of H2S chemistry and biology... biomedical effects. The first international H2S conference was held in 2009

functions as a tumor suppressor downstream of activated CTNNB1 mutants during... TBX3 在人 HCC 标本中的表达。在 Tbx3flox/flox 转基因小鼠中，通过尾静脉注射 c-Met 和ΔN90-β-catenin

        分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
 BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives• To better understand the potential applications of GWAS
• To address practical issues in study design, implementation, and data analysis of GWAS
• To promote interaction and collaboration among researchers who are interested in GWAS
• To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
• To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
• Breast cancer in Chinese populations Xiao-ou Shu
• Genetic association studies of skin cancer Jiali Han
• Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
• Genetic association studies of lung cancer in Chinese populations Daru Lu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
• Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
• Genetic association studies of hypertension in Chinese populations Jiang He
• GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
• Molecular epidemiology of diabetes in Chinese populations Weiping Jia
• Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
• Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
• Genetic structure of Chinese population Li Jin
• High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
• Molecular genetics study of neural tube defect Hongyan Wang
• Risk prediction using genetic variants in prostate cancer Jianfeng Xu
• Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
• Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)• Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
• Genetic epidemiology of skin cancer and breast cancer
• Genome-wide association studies
• Gene-environment interaction• Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
• Genetic epidemiology of hypertension
• Gene-nutrition interaction of cardiovascular disease• Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
• Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
• Genome-wide association studies
• Genetic variants and association study• Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
• Molecular endocrinology and diabetes• Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolism diseases
• Genetic markers for population genetics• Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
• Genetic and molecular epidemiology of lung cancer and glioma
• Genetics of metabolic disease• Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
• Genetic and lifestyle predictors of cancer and other chronic diseases
• Cohort study methodology
• Incorporating biomarkers in risk prediction• Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
• Translational cancer research
• Gene expression profiling
• Cancer genome high-throughput sequencing• Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
• Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)• Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
• Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
• Genetic susceptibility to cancer
• DNA repair and apoptosis phenotype markers• Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
• Genetic epidemiology of prostate cancer
• Genome-wide association and fine mapping analysis
• Risk prediction using genetic markers and other clinicopathologic variables• Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
• Molecular epidemiology of smoking-related cancers
• Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
• Gene-environmental interaction between genetic markers and environmental factors• S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
• High-throughput genotyping and sequencing
• Genetic epidemiology of prostate cancer• Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
• molecular and genetics of complex diseases• Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
• Molecular and genetics of cardiovascular diseases• Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
• Topic of presentation: Molecular epidemiology of stomach cancer
 

弥漫大 B 细胞淋巴瘤（DLBCL）是最为常见的一种侵袭性非霍奇金淋巴瘤（NHL），累及中枢神经系统（CNS）的概率约为 5%。据统计，伴有 CNS 累及的...升高或伴有 1 处以上的结外累及（1B）2. 睾丸累及（1B）或乳腺累及（2B）3. 肾脏及肾上腺累及（2C）或硬膜外腔累及（2D）4. CNS 累及的国际

14-18日在瑞典斯德哥尔摩召开二、主办单位： 欧洲糖尿病协会（EASD）三、组委会成员： 欧洲糖尿病协会（EASD）主席：Bo Ahrén 欧洲糖尿病协会（EASD

进行浅表性磨削，直至出现针尖大小出血点（见图 1A 和 B）。丢弃最初从磨皮器和皮肤上刷下的浅表角质层，然后将表皮刷取物移入含有磷酸盐缓冲溶液的无菌试管，1000 rpm 离心 10 分钟（见图 1C）。图 1.（A）手术使用的手工磨皮器；（B）通过磨削获取的表皮刷取物；（C）离心后的表皮刷取物；（D）胰蛋白酶消化后的

Femoral Head Fractures:A Critical But Frequently Missed Injury

Hyperthyroidism：a practical approach to Dx. AND Rx.

2014年是制药工业重要的一年。这一年制药工业继续变革：崭新机制的创新药研发渐渐成为新药开发的主流，me-too类产品逐渐被边缘化，没有明显临床区分的鸡肋...。安进的双特异性T-细胞结合蛋白（BiTE）Blincyto是另一类革命性的肿瘤免疫疗法，最近获得FDA批准用于治疗费城染色体阴性的前体B细胞急性淋巴细胞白血病

近几年，孤儿药制造商已着迷于这一药物市场，并在小部分患者人群中积累了大量的销售额，规避了大规模市场药物通常面临的仿制药及Me-too类药物竞争。一份新的报告称...预测称。7、依鲁替尼：强生的这款药物在监管审评中获得FDA三项突破性治疗药物资格之后一举成名。这款B细胞癌症药物在2020年将会产生35亿美元的销售额，EP预测

Receptor (CAR) T Cell Therapy for B-Cell Acute Lymphocytic Leukemia (B-cell ALL) in a...，中国陆道培医院的 2 篇口头报道针对 CAR-T 治疗难治性 B-ALL 患者有了新突破。小编为大家摘出来一起学习：《Feasibility

期非大型霍奇金淋巴瘤（nonbulky Hodgkin’s lymphoma）患者的生存率。在这项研究中，加拿大国立癌症研究所临床试验组负责人Ralph M. Meyer博士及其同事将405例既往未接受过治疗的ⅠA期或ⅡA期非大型霍奇金淋巴瘤患者随机分成2组，一组接受单纯ABVD[阿霉素

cell growth and regulates G1/S transition by targeting p21Cip1/Waf1 in hepatocellular carcinoma.Lin J , Huang S , Wu S , Ding J , Zhao Y , Liang L , Tian Q

; Palanisamy, N., Ateeq, B., Kalyana-Sundaram, S. et al.案例简介：在前列腺癌中，尽管包括ETS家族转录因子... Shah, S. P., Kobel, M., Senz, J. et al.案例简介

B7-H1/PD-L1 表达检测肿瘤微环境中活化 T 细胞能够诱导 B7-H1/PD-L1 在肿瘤细胞中的表达。B7-H1/PD-L1 继而通过与活化 T 细胞 PD-1 的相互作用负调控效应 T 细胞。重要的是，B7-H1/PD-L1 在肿瘤细胞的表达与 B7-H1/PD-L1 封闭反应正相关

now.For further information on any of Simcyp's events please contact Kelly

【用药问答】下列物品中毒抢救时，禁忌洗胃的是？（此题不需回答）A.有机磷农药B.浓硫酸C.杀鼠剂D.安眠药正确选项：B解析 :浓硫酸属于强腐蚀性毒物，对胃肠段黏膜具有腐蚀作用，洗胃易发生胃穿孔（B对）。有机磷农药中毒应及早彻底洗胃，洗胃液常用2％碳酸氢钠（A错）。杀鼠剂成分未明，砷、硝酸银、溴化物及不明原因中毒时常

肿瘤微环境中活化 T 细胞能够诱导 B7-H1/PD-L1 在肿瘤细胞中的表达。B7-H1/PD-L1继而通过与活化 T 细胞 PD-1 的相互作用负调控效应T细胞。重要的是，B7-H1/PD-L1 在肿瘤细胞的表达与 B7-H1/PD-L1 封闭反应正相关。R&D Systems 提供的抗体