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Schwend, B.A., M.D.（Kansas City，USA）陈世益（复旦大学华山医院）王予彬（同济大学东方医院）赵 &nbsp...5.青少年半月板损伤6.青少年运动员的肩、肘、髋关节7.髋关节发育不良和脱位8.儿童及青少年脊柱四肢疾患9.儿童

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&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 分子流行病学再揭示人类复杂疾病遗传因素及其与环境因素相互作用发挥重要作用,为人类疾病的风险评估、预防和个性化治疗提供依据。全基因组关联分析（GWAS）为全面系统研究复杂疾病的遗传因素掀开了新的一页，为我们了解人类复杂疾病的发病机制提供了更多的线索。科学家已经在肥胖、糖尿病、冠心病、阿尔茨海默、乳腺癌、前列腺癌、肺癌、胃癌等一系列复杂疾病中进行了全基因组关联研究并找到疾病相关的易感基因，我国科学家也在银屑病、精神病和冠心病等方面开展了GWAS研究并取得成效。国家科技部最新公布了“常见重大疾病全基因组关联分析和药物基因组学研究”的863重点项目，吹响了我国大规模开展GWAS研究的号角。为了让更多的相关研究人员，特别是广大研究生了解GWAS的研究原理和方法，学会设计GWAS的研究和分析实验结果，同时在癌症领域分享海内外研究专家们的成功经验，并期待在GWAS方面进行交流合作,复旦大学和美国Van Andel 研究所将于2009年7月12-14日在上海联合举办上海分子流行病学与GWAS国际 研讨会, 期待各位同道免费参加，请有意者及时将回执返回联系邮箱。免注册费（食宿餐饮费用自理）。名额有限，报名从速！时间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆 上海市邯郸路220号，200433
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹 高歌 联系电话： 021-55664495
回执邮箱： GWAS2009@gmail.com
&nbsp;BackgroundRecent success of genome-wide association studies (GWAS) in the U.S. and Europe has lead to the identification of a large number of genetic variants that are associated with disease risk and progression, including those for cancer and cardiovascular diseases. The discovery of these genetic markers not only improves our understanding of disease etiology, but also contributes significantly to risk prediction, early detection, and targeted treatment of diseases.Although GWAS have been used in Chinese populations to identify Chinese-specific risk-associated genetic variants for several common diseases such as breast cancer and psoriasis, many more GWAS are needed for various diseases. A better understanding of the importance of GWAS and a better knowledge of study design and data analysis of GWAS will further promote broad application of GWAS in China. This symposium which will cover genetic epidemiology and GWAS in China is organized to serve this purpose. We have invited a group of experts in this area from the U.S. and China to share their experience in GWAS, and we hope to foster an environment which will encourage an open discussion among all participants.
Objectives&bull; To better understand the potential applications of GWAS
&bull; To address practical issues in study design, implementation, and data analysis of GWAS
&bull; To promote interaction and collaboration among researchers who are interested in GWAS
&bull; To explore other important studies after GWAS: gene-environment interaction, risk prediction, and functional analyses
&bull; To consider issues and implications related to genomic and personalize medicine
Organizing committeeThe organizing committee consists of four members:
Dr. Jianfeng Xu (Co-Chair)
Dr. Daru Lu (Co-Chair)
Dr. Li Jin (Co-Chair ,Advisor)
Dr. Qingyi Wei (Co-Chair, Advisor)
PresentationsSession I: Genetic epidemiology and GWAS of cancer
&bull; Breast cancer in Chinese populations Xiao-ou Shu
&bull; Genetic association studies of skin cancer Jiali Han
&bull; Genetic variants in the MC1R gene and risk of cutaneous melanoma Qingyi Wei
&bull; Genetic association studies of lung cancer in Chinese populations Daru Lu
&bull; Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao Zhou
&bull; Molecular epidemiology of stomach cancer Weimin YeSession II: Genetic epidemiology and GWAS of other diseases
&bull; Genetic association studies of hypertension in Chinese populations Jiang He
&bull; GWAS of Autoimmune Diseases (Psoriasis, etc.) in Chinese populations Wei Huang
&bull; Molecular epidemiology of diabetes in Chinese populations Weiping Jia
&bull; Molecular genetics study of hypertension in Chinese populations Dingliang Zhu
&bull; Molecular epidemiology of hepatitis, liver cirrhosis and hepatocarcinoma Gangqiao ZhouSession III: Post-GWAS studies
&bull; Genetic structure of Chinese population Li Jin
&bull; High-throughput genotyping for GWAS and fine mapping studies Siqun Lilly Zheng
&bull; Molecular genetics study of neural tube defect Hongyan Wang
&bull; Risk prediction using genetic variants in prostate cancer Jianfeng Xu
&bull; Gene-environmental interaction in smoking related cancer Zuo-Feng Zhang
&bull; Cancer Somatic Genomics Bin TehSession IV: Short presentations by participants and discussion
Registration时　　间： 2009年7月12－14日
报到地点： 复旦大学卿云楼宾馆大厅 上海市邯郸路220号 (200433)
会议地点： 复旦大学逸夫楼报告厅
联 系 人： 赵雪莹，高歌 (Shanghai, China)；Tamara Adams (U.S.)
联系电话： 21-55664495 (Shanghai, China)；336-713-7532 (U.S.)
回执邮箱： GWAS2009@gmail.com (Shanghai, China)；tsadams@wfubmc.edu (U.S.)
Invited speakers (alphabetic)&bull; Jiali Han, Ph.D., is an Assistant Professor of Medicine at Harvard Medical School. His major research areas are:
&bull; Genetic epidemiology of skin cancer and breast cancer
&bull; Genome-wide association studies
&bull; Gene-environment interaction&bull; Jiang He, M.D. Ph.D., is a Professor and Chair of Epidemiology, Tulane University School of Public Health., U.S.A. His major research areas are:
&bull; Genetic epidemiology of hypertension
&bull; Gene-nutrition interaction of cardiovascular disease&bull; Wei Huang, Ph.D., is a Professor and Executive Deputy Director of Chinese National Human Genome Center at Shanghai, China. Her major research areas are:
&bull; Genetic susceptibility to autoimmune diseases, cardiovascular diseases and cancer.
&bull; Genome-wide association studies
&bull; Genetic variants and association study&bull; Weiping Jia M.D., is a professor of endocrinology at Shanghai Institute of Diabetes, Shanghai No.6 People’s Hospital, Shanghai Jiaotong University, Her major research area is:
&bull; Molecular endocrinology and diabetes&bull; Li Jin, Ph.D, is a Professor of Genetics and vice President of Fudan University, China. His major research areas are:
&bull; Genetic and molecular epidemiology of lung cancer and glioma
&bull; Genetics of metabolism diseases
&bull; Genetic markers for population genetics&bull; Daru Lu, Ph.D, is a Professor of Genetics and Vice Dean of School of Life Sciences, Fudan University, China. His major research areas are:
&bull; Genetic and molecular epidemiology of lung cancer and glioma
&bull; Genetics of metabolic disease&bull; Xiao-ou Shu, M.D, Ph,D, is a Professor of Medicine in the Department of Medicine at the Vanderbilt University School of Medicine, U.S.A. Her major research areas are:
&bull; Genetic and lifestyle predictors of cancer and other chronic diseases
&bull; Cohort study methodology
&bull; Incorporating biomarkers in risk prediction&bull; Bin Teh, M.D, is a Distinguished Scientific Investigator at Van Andel Institute, U.S.A. His major research areas are:
&bull; Translational cancer research
&bull; Gene expression profiling
&bull; Cancer genome high-throughput sequencing&bull; Hongyan Wang, Ph.D, is a professor of genetics at School of Life sciences, Fudan University, China. Her major research area is:
&bull; Molecular genetics and epidemiology of birth defects (deformity of neural tube, congenital heart disease, etc.)&bull; Qingyi Wei, M.D, Ph.D, is a Professor of Epidemiology at The University of Texas M. D. Anderson Cancer Center, U.S.A. His major research areas are:
&bull; Molecular epidemiology of DNA repair, apoptosis, and skin cancer and head and neck cancer
&bull; Genetic susceptibility to cancer
&bull; DNA repair and apoptosis phenotype markers&bull; Jianfeng Xu, M.D, Dr.PH, is a Professor of Epidemiology and Cancer Biology and Director of the Center for Cancer Genomics at Wake Forest University School of Medicine, U.S.A. His major research areas are:
&bull; Genetic epidemiology of prostate cancer
&bull; Genome-wide association and fine mapping analysis
&bull; Risk prediction using genetic markers and other clinicopathologic variables&bull; Zuo-Feng Zhang, M.D., Ph.D, is a Professor of Epidemiology at UCLA School of Public Health, U.S.A. His major research areas are:
&bull; Molecular epidemiology of smoking-related cancers
&bull; Confirmation studies of SNPs identified in genome-wide association studies in smoking-related cancers
&bull; Gene-environmental interaction between genetic markers and environmental factors&bull; S. Lilly Zheng, M.D, is a Professor of Medicine and Director of the Genotyping Laboratory at Wake Forest University School of Medicine. U.S.A. Her major research areas are:
&bull; High-throughput genotyping and sequencing
&bull; Genetic epidemiology of prostate cancer&bull; Gangqiao Zhou, Ph.D, is a Professor of Medical Genetics and Genomics in National Academy of Military Medical Science. His major research area is:
&bull; molecular and genetics of complex diseases&bull; Dingliang Zhu, M.D, is a professor of cardiology at Shanghai Institute of Hypertension, Shanghai, China. His major research area is:
&bull; Molecular and genetics of cardiovascular diseases&bull; Weimin Ye, Ph.D, is a Professor of Medical Epidemiology at Karolinska Institutet, Sweden. His major research areas are: Etiology of upper gastrointestinal diseases
&bull; Topic of presentation: Molecular epidemiology of stomach cancer
&nbsp;

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后患者的的身体活动情况在术后能否得到提高却一直没有明确的研究。针对上述问题，澳大利亚的PaulaHardingD医生首次使用GT1M...后进行标准的物理治疗，包括术后1天在助行器及理疗师帮助下开始负重行走，并进行床上运动练习。使用GT1M加速器测量患者术前及术后6个月时的运动情况，并对患者疼痛、髋

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Kenneth M.C. Cheung等在中国南方做了一项基础人群的横断面研究，研究共纳入2599名居民（其中男性1040名，女性1599名，平均年龄41.9岁）。参加者...有腰椎间盘变性。有腰椎间盘变性者的BMI比没有腰椎间盘变性者显著高（23.3 kg/m2 对21.7 kg/m2; P<0.001）。研究发现腰椎间盘变性随BMI

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挥了某些其他作用。于是，美国杜克大学医学中心和哥伦比亚大学联合开展了一项研究以揭示其中的原因。这项研究以体重指数(BMI)超过35 kg/m2的2型糖尿病... kg/m2的重度肥胖2型糖尿病患者的治疗选择之一，但是只有不到一半的糖尿病患者达到了如此高的超重标准。代表了全球200多家糖尿病团体的国际糖尿病联盟(IDF)最近也提出