提供了技术保障。Label-free shotgun：无标签标记的定量蛋白质组学研究，依赖于繁杂的信息分析完成定量过程，主要有两种：信号强度和谱图计数法[1

of about 22-nucleotide noncoding RNAs that have been highly conserved during evolution and play a significant role in haematopoiesis, including differentiation

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Background. Hepatitis C virus (HCV) is spread through direct contact with blood, although alternative routes of transmission may contribute to the global burden. Perinatal infection occurs in up to 5% of HCV-infected mothers, and presence of HCV RNA in breast milk has been reported. We investigated the influence of breast milk on HCV infectiousness.Methods/Results. Human breast milk reduced HCV infectivity in a dose-dependent manner. This effect was species-specific because milk from various animals did not inhibit HCV infection. Treatment of HCV with human breast milk did not compromise integrity of viral RNA or capsids but destroyed the lipid envelope. Fractionation of breast milk revealed that the antiviral activity is present in the cream fraction containing the fat. Proteolytic digestion of milk proteins had no influence on its antiviral activity, whereas prolonged storage at 4°C increased antiviral activity. Notably, pretreatment with a lipase inhibitor ablated the antiviral activity and specific free fatty acids of breast milk were antiviral.Conclusions. The antiviral activity of breast milk is linked to endogenous lipase-dependent generation of free fatty acids, which destroy the viral lipid envelope. Therefore, nursing by HCV-positive mothers is unlikely to play a major role in vertical transmission.

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论文识别出了人类和犬乳腺肿瘤的重要相似之处和差别，为使用犬模型系统的未来研究提供了一个强有力的平台。\r\n\r\n

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乳腺癌BOLERO-2研究最终结果：近年来乳腺癌治疗中关于依维莫司的研究数据令人鼓舞，基于BOLERO-2临床研究结果于FDA获批。近期BOLERO-2研究的最终结果发表，确认了对ER+，HER2-的晚期乳腺癌患者，在内分泌治疗进展后进行内分泌和mTOR通路的双重封锁能够带来PFS获益。

microRNA-34a tp53在白血病发病的作用

简介The Leipzig University (German: Universit?t Leipzig), located in Leipzig in the Free State of Saxony, Germany, is one of the oldest

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Family physicians play a crucial role in the management and ongoing care of patients with Alzheimerdisease (AD). This article reviews the effects

Live OCD Free是一个新开发的app，它旨在帮助治疗强迫症的衰弱症状。根据MassHighTech.com网站的相关介绍，此新的...醒他们不要屈服于自己的强迫症以及监视器报告的焦虑水平。根据ABCNews.com的报道，用户可以趋向于他们的焦虑水平，而且一旦此焦虑水平下降，他们将会承受更具

Dendrites play a central role in neuronal information processing by integrating thousands of synaptic inputs to generate a meaningful action potential