PMLiVE 于 10 月 19 日报道，礼来显著加大对免疫肿瘤的关注，该公司与德国生物制药集团 CureVac 签署了一项价值逾 18 亿美元的协议。这对合作伙伴将开发多达 5 款癌症疫苗产品，并在合作过程中有可能开发新的药物。该协议的核心是信使 RNA(mRNA) 技术，这是该技术在免疫肿瘤学领域的首次广泛探索

卒中的院前干预17:35-17:50 　POC测定在卒中预防中的价值（管阳太） 17:50-18:10 　卫星会议 18:10 　　　“

Background. Hepatitis C virus (HCV) is spread through direct contact with blood, although alternative routes of transmission may contribute to the global burden. Perinatal infection occurs in up to 5% of HCV-infected mothers, and presence of HCV RNA in breast milk has been reported. We investigated the influence of breast milk on HCV infectiousness.Methods/Results. Human breast milk reduced HCV infectivity in a dose-dependent manner. This effect was species-specific because milk from various animals did not inhibit HCV infection. Treatment of HCV with human breast milk did not compromise integrity of viral RNA or capsids but destroyed the lipid envelope. Fractionation of breast milk revealed that the antiviral activity is present in the cream fraction containing the fat. Proteolytic digestion of milk proteins had no influence on its antiviral activity, whereas prolonged storage at 4°C increased antiviral activity. Notably, pretreatment with a lipase inhibitor ablated the antiviral activity and specific free fatty acids of breast milk were antiviral.Conclusions. The antiviral activity of breast milk is linked to endogenous lipase-dependent generation of free fatty acids, which destroy the viral lipid envelope. Therefore, nursing by HCV-positive mothers is unlikely to play a major role in vertical transmission.

Background. Targeting host-cell pathways to increase the potency of nucleoside/nucleotide analog reverse transcriptase inhibitors (NRTIs) is an important strategy for clinical investigation. Resveratrol is a natural product that inhibits cellular ribonucleotide reductase, prolonging the S phase of the cell cycle and preferentially lowering dATP levels.Methods. We performed in vitro evaluation of resveratrol on the antiviral activity of adenosine analog tenofovir (TFV) against sensitive and drug-resistant human immunodeficiency virus type 1 (HIV-1), from subtypes B and C, in primary cells.Results. Resveratrol enhanced the antiviral activity of TFV by up to 10-fold and restored susceptibility of TFV-resistant viruses. Resveratrol prevented wild-type HIV-1 from developing phenotypic resistance to TFV. Notably, resveratrol enhanced TFV activity against sensitive and resistant HIV-1 from both subtypes B and C.Conclusions. Prolonged wide-scale use of thymidine analogs in the setting of viral failure has limited the efficacy of second-line NRTI-based regimens in Africa. Moreover, the extensive use of ddI and d4T has led to high frequencies of the K65R mutation, further compromising TFV efficacy. In light of increasing resistance to commonly used NRTIs in global HIV treatment programs, targeting nucleoside biosynthesis with resveratrol, or derivatives with improved bioavailabilities, is a potential strategy to maintain, enhance, and restore susceptibility of commonly used NRTIs.

Organized by the professional organization- China Liaoning Society for Immunology and Institute of Immunology, China Medicinal University, the 1st Annual International Symposium on Immune Diseases is designed to provide a small and cross disciplinary carefully selected current topics in immunology, from the basic science to clinical treatment. Over 300 global specialists are anticipated to get together to present and share their cutting-edge developments and up-to-date researches in pathogenesis, diagnosis, prevention, treatment, and clinical presentation of important immune diseases. We are convinced ISID-2010 will definitely offer an idea platform for promotion and collaboration for relevant companies and institutes of their technologies, products and services.The 1st Annual International Symposium on Immune Disease 2010 (ISID-2010) will include either oral or poster presentations in both academic and industrial settings. All the faculty, academic, clinical and industrial researchers will have their own presentation means to join this event.The conference venue, Beijing is the bilingual and multicultural capital city of China. On August 8, 2008, Beijing brought the world a great surprise for the Olympics opening ceremony. We are sure Beijing will provide an ideal location for what promises to be an exciting and memorable meeting.We look forward to seeing you in Beijing for a stimulating and enjoyable Conference!会议主席：中国医科大学院士 陈洪铎教授会议副主席：中国医科大学 吕昌龙教授会议执行主席：中国医科大学 单凤平教授

第 18 届全国临床肿瘤学大会（CSCO2015）上，丁香园有幸邀请到管忠震教授和我们分享了 CSCO 成立之初的事。随着会员数越来越多，CSCO 组织了一个继续教育为主的平台，推动了临床研究的发展。ccvideo

7月18日，CFDA官网分五批公布了有关人事任免的通知，这些通知的签署日期从6月5日到6月20日之间。其中，任免信息如下（排序不分先后）：1、任命孙咸泽同志为药品安全总监；2、任命郭文奇同志为食品安全总监；3、免去吴浈、焦红同志兼任的食品药品安全总监职务(注：吴浈目前为总局副局长、党组成员，焦红为副局长)。4、任命陈

Ⅰ『目的』 本指南旨在帮助医师在成人及儿童患者施行18F-FDG PET/CT肿瘤显像过程中如何介绍、操作、解释和报告检查结果。 Ⅱ『背景信息及定义』 PET是一种断层闪烁显像技术，它通过探测引入机体的正电子核素发生衰变时释放出的正电子所发射的湮没光子来反映示踪剂在机体局部组织内的分布。18F-FDG PET是通过

医疗队的我院 18 名医疗队员，在来势汹汹的疫情面前，他们主动请缨，听从祖国和人民的召唤，告别家乡告别亲人，肩负着我院 6000 名职工和孔孟之乡 900 万...后，他们稍事休息，立即投入紧张的战斗。第一批队员所在的医疗队负责的病区有 120 张床位，随着危重患者的增加，之后不久又新增加了一个 18 张床位的重症监护

至 1846 年的气道管理进行了系统的回顾分析。18 世纪可谓是麻醉发展的蓬勃时期。18 世纪中叶，1772 年 Pristley 发现氧化亚氮（笑气），1884 年...，越来越多的麻醉药物被合成并应用于临床。作者认为 1700 年至 1846 年为麻醉时代，且基本气道管理现代史始于出现死亡复苏案例下 18 世纪初。历史见证

编者按：不偏颇，也不推责，急诊患者等医生18分钟错过治疗时间 倒地身亡的新闻背后，不完善的应急机制、匮乏的医疗资源及可能解决办法，才是该有的态度。近日，一则「急诊患者等医生 18 分钟错过治疗时间 倒地身亡」的新闻进入了视线，因胸闷心慌，勉县男子汤润武去勉县医院看病，没想到急诊科医生先让心电图室做检查。然而，心电图室

为了安抚股东们的心，赛诺菲在裁掉其首席执行官魏巴赫克里斯之后，已迅速开展新的行动。该公司声称，到2020年将推出多达18个新产品。魏巴赫在今年初还在效力的赛诺菲对其临床后期产品的推出寄予了厚望，该公司表示，新产品在上市的第一个五年期间，具有带来超过300亿欧元销售额的潜力。代理首席执行官兼主席温伯格一次交易更新时表示

范围内代表1.800名参与者，对黑色素瘤和非黑色素瘤皮肤癌的基础科学，预防和治疗进行讨论。2020年第18届世界皮肤癌大会将于6月24-27日在阿根廷

2021 年 7 月 23 日凌晨，河南省直第三人民医院东院区急诊收治了一名 18 岁的大学生。据急重症医学中心主管医生孟双全介绍，这名...。情况紧急，介入科陈清亮主任第一时间为他进行了脑血管造影，排除了动脉瘤。患者清醒了，在沟通中了解到，这名 18 岁的大男孩叫吴懿轩，是内蒙古乌海市人，今年