庞大的处方药销售市场的无疑是全球的医药巨头们。EvaluatePharma推测，2020年全球处方药销售Top20公司的销售额合计可达5795亿美元，占...稳居全球处方药销售Top20公司的榜首。而凭借出色的HIV药物特许经营权和最近获批并赢得极佳预测的丙肝治疗药物Sovaldi，2020年吉利德科学

。临床神经病学临床神经病学相关杂志 TOP 20 中，IF 呈上升趋势的占了一多半，分数下滑的杂志只有 6 本（具体见表格 1 中红色箭头所示）。排名前 5 的杂志...，而 NEURO-ONCOLOGY 也从去年的 15 名进步到第 9。另外，今年有 4 本期刊新登 TOP 20：CEPHALALGIA（排名 13

、58、6、71、79、316、323、324、365、370、M358、2号观光线路公交至北大医院站由正门进入；2、 乘111、15、222、328

130亿美元，包括私营医院在内的医疗支出高达365亿美元。展品范围：疗器械与仪器设备：医用电子仪器，医用超声仪器，医用X线设备，医用

（www.cpa.org.cn）和中国药学会医院药学专业委员会网站（www.cpahp.org.cn）医疗会议展览网（www.365medical.org）查询

医药网\东方保健品招商网\湖北医药网\东方医药商情网\新药招商网\环球医药信息网\北讯医药\健康365\食品商务网\食品搜索网\食品医药网\食品展会网\食品展览网

Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

的预期。总体来看，处方药销售较为平稳，虽然经历全球经济低谷，制药企业的研发投入较为稳定，显示出企业对未来的预期比较乐观。图1 TOP50制药企业处方药销售及研发投入情况(单位：亿美元)而作为制药行业旗舰的TOP10企业，他们的处方药销售收入占到TOP50企业销售总收入的五成以上，研发投入金额也占到总投入的六成左右，他们

对照组相比，帕金森病的累积发病率较高。同对照组相比，使用唑吡坦治疗的患者累计限定日剂量为28–90mg、91-365mg和超过365mg的调整后风险比分

总体应答率。TOP2A基因位于HER2旁，该基因的扩增或缺失，或许能预测患者对蒽环类药物的治疗反应，但是，有一些研究者提示与TOP2A基因扩增相比，TOP2A蛋白的表达或许与蒽环类药物获益更为相关。对于低危HER2扩增的早期乳腺癌患者而言，无论其TOP2A状态如何，四疗程多烯紫杉醇联合环磷腺