据估计有1/3的女性在人生中有选择终止妊娠的经历。药物流产（TOP）用药规则通常是单次口服200 mg米非司酮，观察24-48小时后再使用800 μg米索前列醇（通常阴道给药）。未排除妊娠的女性通常使用超声作为随访常规检查。超声能可靠地排除持续妊娠，避免不必要的药物和外科干预。但超声价格比较昂贵，且对技术要求高。其他

美国《基因工程与生物技术新闻》杂志（Genetic Engineering & Biotechnology News）近日发表了题为“Top 20 R&D Spenders among Tool and Tech Companies”的文章，盘点了2013年度研发投入前

Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

，并在脑发育期间显示水平升高的独特表观遗传标记；同时表明 5-hmC 在基因激活中起作用的证据已通过 5-hmC 与 H3K9 和 H3K27 三甲基化之间的... and beyond. Nat Rev Genet. 2017;18(9):517-534.Ginder GD, Williams DC. Readers of DNA

近日，数字医学领域全球顶级期刊《npj Digital Medicine》（Nature 旗下权威学术期刊，中科院医学大类 1 区 Top 期刊，2024 年影响因子 15.1）发布了一项来自中国科研团队的最新研究成果——全球首个用于评估医疗 AI 临床适用性的权威标准：「临床安全-有效性双轨基准」（CSEDB