Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

;Edition/K6460 液相色谱串联质谱系统结合试剂盒定量分析血液中的同型半胱氨酸案例 2：使用安捷伦 InfinityLCClinicalEdition/K6460 液相色谱串联质谱系统分析血清中的 25-羟基维生素 D

母乳喂养，在老家私人医疗机构出生，是否补充维生素 k1 不详，需进一步完善颅脑 CT。3. 最终明确诊断（1）辅助检查回报颅脑 CT 提示脑室内出血。（2）最后诊断晚发性维生素 k 缺乏症并颅脑出血（3）治疗立即补充维生素 K1、输血浆改善出血症状，输血纠正贫血。适当使用甘露醇减低颅高压；其他对症支持治疗及神经外科协助诊治

高血压是心血管医生临床工作中的常见疾病，那么 2015 年度心血管时间上高血压文章琅琊榜的 TOP 8 是哪些呢，让我们逐一盘点。1. 《2015 年度高血压研究领域要闻盘点》近日，河北省人民医院郭艺芳教授对今年高血压研究领域的诸多新进展进行了回顾。在 AHA 2015 年会上， SPRINT 研究结果正式公布