谈起 《Advanced Science》和《Science Advances》这两本 TOP 级神刊，你还傻傻分不清楚？作为 Science 的子刊... Q1 区，在中科院分区方面略有不同。Science Advances 中科院分区：大类学科综合性期刊 1 区；小类学科综合性期刊 1 区；TOP 期刊，非综述期刊

转眼又是一月，用药助手又有新的用药经验文章榜单啦！你离用药高手，还有多远呢？四月用药经验 TOP 10患者休克危在旦夕：升压药如何选用？想破脑袋的「低钾... 200 多的患者……降糖不佳就换药？先看看最佳服药时间四月用药问答 TOP 10用药问答：四种常见的神经病理性疼痛，如何用药？用药问答：发生心源性休克如何抢救？用药

据估计有1/3的女性在人生中有选择终止妊娠的经历。药物流产（TOP）用药规则通常是单次口服200 mg米非司酮，观察24-48小时后再使用800 μg米索前列醇（通常阴道给药）。未排除妊娠的女性通常使用超声作为随访常规检查。超声能可靠地排除持续妊娠，避免不必要的药物和外科干预。但超声价格比较昂贵，且对技术要求高。其他

美国《基因工程与生物技术新闻》杂志（Genetic Engineering & Biotechnology News）近日发表了题为“Top 20 R&D Spenders among Tool and Tech Companies”的文章，盘点了2013年度研发投入前

，并在脑发育期间显示水平升高的独特表观遗传标记；同时表明 5-hmC 在基因激活中起作用的证据已通过 5-hmC 与 H3K9 和 H3K27 三甲基化之间的... and beyond. Nat Rev Genet. 2017;18(9):517-534.Ginder GD, Williams DC. Readers of DNA

Intensive course:‘Model-based drug development: Incorporating population variability into mechanistic prediction of PK and modelling PK-PD' This event runs from 4th – 8th March 2013 at the Crowne Plaza Century Park, Shanghai, China.Delegates will learn how to simulate:• Metabolic drug clearance (CL)
• Metabolic drug-drug interactions (DDIs)
• Gut first-pass metabolism
• Oral drug absorption incorporating food effects and the impact of dosage form
• Effect of transporters and enterohepatic recirculation on kinetics and DDIs
• Drug distribution to different organs
• Population variability in drug concentration-time profiles
• Variation in kinetics in specific populations (paediatrics, ethnic groups, various disease populations)
• Data for therapeutic proteins
• Pharmacodynamic effects of different compounds
• Time-course of drug in plasma that fits observed clinical data (achieved by combining fitting techniques with IVIVE, PBPK and drug specific in vitro data)Click here to download the workshop flyer.Registration:

Online booking for Simcyp events is now handled through the Simcyp Members’ Area. Your saved profile is automatically captured on the booking form so there is no need to re-enter your contact details. Click here to link to the booking forms – you will be prompted for your Simcyp Members’ Area user name (email address) and password. If you have forgotten your log-in credentials please follow the instructions on-screen.If you have not yet registered for the Members’ Area please sign up now.For further information on any of Simcyp's events please contact Kelly Turton.Language AssistanceOur expert course tutors include many fluent Chinese speakers who will be able to assist with small group discussions and translate questions and answers after the lecture sessions. **Please note that the lectures and all course material will be in English**For Details Please Visitwww.simcyp.com/ProductServices/Workshops/20130304_Shanghai.htm?p=1

;Edition/K6460 液相色谱串联质谱系统结合试剂盒定量分析血液中的同型半胱氨酸案例 2：使用安捷伦 InfinityLCClinicalEdition/K6460 液相色谱串联质谱系统分析血清中的 25-羟基维生素 D

母乳喂养，在老家私人医疗机构出生，是否补充维生素 k1 不详，需进一步完善颅脑 CT。3. 最终明确诊断（1）辅助检查回报颅脑 CT 提示脑室内出血。（2）最后诊断晚发性维生素 k 缺乏症并颅脑出血（3）治疗立即补充维生素 K1、输血浆改善出血症状，输血纠正贫血。适当使用甘露醇减低颅高压；其他对症支持治疗及神经外科协助诊治